Pflügers Archiv

, Volume 399, Issue 2, pp 152–154 | Cite as

Is calmodulin involved in the regulation of gap junction permeability?

  • Camillo Peracchia
  • Giovanni Bernardini
  • Lillian L. Peracchia
Letters and Notes


The cell-to-cell channels of gap junctions mediate the direct exchange of ions and small metabolites between neighboring cells. A number of studies have shown that these channels close when the intracellular free calcium or hydrogen concentration increases, the result being cell-to-cell uncoupling. Since most of the calcium-activated biological phenomena are mediated by calmodulin (CaM), an obvious question is whether or not CaM is involved in the mechanism of cell coupling regulation. Data from the present study, showing the inhibitory effects of a calmodulin blocker on electrical uncoupling in Xenopus embryo cells, suggest a possible CaM participation in the uncoupling mechanism.

Key words

Gap junctions calmodulin trifluoperazine Xenopus embryo cell coupling 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Camillo Peracchia
    • 1
  • Giovanni Bernardini
    • 1
  • Lillian L. Peracchia
    • 1
  1. 1.Department of PhysiologyUniversity of Rochester, School of Medicine and DentistryRochesterUSA

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