Journal of inclusion phenomena

, Volume 2, Issue 1–2, pp 91–98 | Cite as

Optical resolution by inclusion complex formation

  • Fumio Toda
  • Koichi Tanaka
Review Papers


Novel optical resolutions of guest compounds by inclusion complex formation with optically active host compound are reviewed. Tertiary acetylenic alcohols, cyanohydrins, and secondary alcohols were resolved by complexation with alkaloids such as brucine or sparteine. Cycloalkanones, 2,3-epoxycyclohexanones, and some other neutral compounds were resolved by complex formation with optically active diacetylenic diol. Mutual optical resolution of bis-β-naphthol and sulfoxides by complex formation was also reviewed.


Alcohol Organic Chemistry Alkaloid Complex Formation Sulfoxide 
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  1. 1).
    F. C. McGrew and R. Adams,J. Am. Chem. Soc.,59, 1497 (1937); I. Iwai and K. Tomita,J. Pharm. Soc. Jap.,80, 160 (1960); S. R. Landor and J. Evans,J. Chem. Soc., 2553 (1965); K. Mori and T. Ebata,Tetrahedron Lett.,37, 1343 (1981).Google Scholar
  2. 2).
    M. M. Midland, D. C. McDowell, R. L. Hatch, and A. Tramontano,J. Chem. Soc.,102, 867 (1980); M. Nishizawa, Y. Yamada, and R. Noyori,Tetrahedron Lett.,22, 247 (1981)Google Scholar
  3. 3).
    T. Mukaiyama and S. Suzuki,Chem. Lett., 255 (1980).Google Scholar
  4. 4).
    F. Toda, K. Tanaka, and H. Ueda,Tetrahedron Lett.,22, 4669 (1981).Google Scholar
  5. 5).
    F. Toda, K. Tanaka, H. Ueda, and T. Ōshima,Israel J. Chem. in press.Google Scholar
  6. 6).
    F. Toda, K. Tanaka, H. Ueda, and T. Ōshima,J. Chem. Soc., Chem. Commun., 743 (1983).Google Scholar
  7. 7).
    F. Toda and K. Tanaka,Chem. Lett., 661 (1983).Google Scholar
  8. 8).
    F. Toda and K. Akagi,Tetrahedron Lett., 3695 (1968); F. Toda, K. Tanaka, H. Hart, D. L. Ward, H. Ueda, and T. Ōshima,Nippon Kagaku Kaishi, 239 (1983).Google Scholar
  9. 9).
    F. Toda, K. Tanaka, T. Omata, K. Nakamura, and T. Ōshima,J. Am. Chem. Soc.,105, 5151 (1983).Google Scholar
  10. 10).
    K. Tanaka and F. Toda,J. Chem. Soc., Chem. Commun., 1513 (1983).Google Scholar
  11. 11).
    F. Toda and K. Tanaka, unpublished data.Google Scholar
  12. 12).
    F. Toda, K. Tanaka, and S. Nagamatsu,Tetrahedron Lett.,25, 4929 (1984).Google Scholar
  13. 13).
    F. Toda, K. Tanaka, and T. C. W. Mak,Chem. Lett. 2085 (1984).Google Scholar

Copyright information

© D. Reidel Publishing Company 1984

Authors and Affiliations

  • Fumio Toda
    • 1
  • Koichi Tanaka
    • 1
  1. 1.Department of Industrial Chemistry, Faculty of EngineeringEhime UniversityMatsuyamaJapan

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