Archives of Orthopaedic and Trauma Surgery

, Volume 112, Issue 4, pp 163–166 | Cite as

Cellular and humoral immune responses after fresh meniscal allografts in mice

A preliminary report
  • M. Ochi
  • Y. Ikuta
  • O. Ishida
  • M. Akiyama
Original Articles


To date, no study of allogeneic meniscal transplantation has investigated both the host cellular immune response and the humoral immune response. Using inbred mice, we examined cellular immunity to meniscal allografts by assaying mixed lymphocyte culture and investigated humoral immunity through a complement-dependent cytotoxity test. The level of the stimulation index of the mixed lymphocyte culture seen after placing fresh meniscal allografts subcutaneously was not significantly higher than when isograft controls were similarly placed. Following placement of the allografts, no specific antibodies were detected in serum throughout the 24-week period after grafting. Thus, in mice, fresh meniscus apparently is not immunogenic. Our results tentatively suggest that a fresh allogeneic meniscus might be transplanted without any special treatment to decrease its immunogenicity.


Special Treatment Specific Antibody Humoral Immune Response Cellular Immune Response Cellular Immunity 
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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • M. Ochi
    • 1
  • Y. Ikuta
    • 1
  • O. Ishida
    • 1
  • M. Akiyama
    • 2
  1. 1.Department of Orthopedic SurgeryHiroshima University School of MedicineHiroshimaJapan
  2. 2.Department of RadiobiologyRadiation Effect Research FoundationHiroshimaJapan

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