Abstract
The crystal structures of two forms of β-cyclodextrin barbital complexes (Form I and Form II) were investigated by X-ray analysis. In Form I crystal, two β-cyclodextrin(β-CyD) molecules including two barbital molecules form a dimeric structure by the hydrogen bonds among their secondary hydroxyl groups. The unit cell volume of Form II is about twice as large as that of Form I and there exist two β-CyD dimers in Form II. Although the (Host)/(Guest) ratio is 1/1, only one barbital molecule can be found in Form II at the present stage. The sinilarities and differences between the two crystal structures are mainly discussed here.
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Nakanishi, I., Arai, M., Fujiwara, T. et al. X-ray structural studies on two forms of β-cyclodextrin barbital complexes. Journal of Inclusion Phenomena 2, 689–699 (1984). https://doi.org/10.1007/BF00662237
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DOI: https://doi.org/10.1007/BF00662237