Journal of inclusion phenomena

, Volume 2, Issue 3–4, pp 645–654 | Cite as

Evaluation of cyclodextrin polymer as a disintegrating agent

  • Fenyvesi Éva
  • Nagai Tsuneji
  • Antal Balázs
  • Zsadon Béla
  • Szejtli József
Article

Abstract

Cyclodextrin polymer was compared to other well known disintegrants concerning the swelling properties /water uptake, moisture uptake, hydration capacity, sedimentation volume in water/. Its high disintegrating effect was proved in directly compressed tablets as well as in tablets made by wet granulation. A remarkable improvement in tablet properties was observed. Not only the disintegration of tablets and the dissolution of the drug was accelerated but also the hardness increased when CDP was used as disintegrant.

Keywords

Polymer Hydration Organic Chemistry Sedimentation Water Uptake 

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References

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Copyright information

© D. Reidel Publishing Company 1984

Authors and Affiliations

  • Fenyvesi Éva
    • 1
  • Nagai Tsuneji
    • 2
  • Antal Balázs
    • 1
  • Zsadon Béla
    • 3
  • Szejtli József
    • 1
  1. 1.Chinoin Chemical and Pharmaceutical WorksBudapestHungary
  2. 2.Faculty of Pharmaceutical SciencesHoshi UniversityTokyoJapan
  3. 3.Department of Chemical TechnologyEötvös L. UniversityBudapestHungary

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