Journal of inclusion phenomena

, Volume 2, Issue 3–4, pp 645–654 | Cite as

Evaluation of cyclodextrin polymer as a disintegrating agent

  • Fenyvesi Éva
  • Nagai Tsuneji
  • Antal Balázs
  • Zsadon Béla
  • Szejtli József


Cyclodextrin polymer was compared to other well known disintegrants concerning the swelling properties /water uptake, moisture uptake, hydration capacity, sedimentation volume in water/. Its high disintegrating effect was proved in directly compressed tablets as well as in tablets made by wet granulation. A remarkable improvement in tablet properties was observed. Not only the disintegration of tablets and the dissolution of the drug was accelerated but also the hardness increased when CDP was used as disintegrant.


Polymer Hydration Organic Chemistry Sedimentation Water Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Zsadon, B., Fenyvesi, É.:Proc. 1st Int. Symp. Cyclodextrins /Ed.: Szejtli, J./, Akadémiai Kiadó /1982/ p. 327.Google Scholar
  2. 2.
    Wiedenhof, N.:Stärke,21 /1969/ 163Google Scholar
  3. 3.
    Fenyvesi, É., Antal, B., Zsadon, B., Szejtli, J.:Pharmazie,39, /1984/ 473Google Scholar
  4. 4.
    Fenyvesi, É., Shirakura, O., Szejtli J., Nagai, T.:Chem. Pharm. Bull. 32 /1984/ 665Google Scholar
  5. 5.
    Takayama, K., Nambu, N., Nagai, T.:Chem. Pharm. Bull. 32 /1984/ 1936Google Scholar
  6. 6.
    Fenyvesi, É., Takayama, K., Szejtli, J., Nagai, T.:Chem. Pharm. Bull. 32 /1984/ 670Google Scholar
  7. 7.
    Szejtli, J., Vikmon, M.: unpublished results.Google Scholar

Copyright information

© D. Reidel Publishing Company 1984

Authors and Affiliations

  • Fenyvesi Éva
    • 1
  • Nagai Tsuneji
    • 2
  • Antal Balázs
    • 1
  • Zsadon Béla
    • 3
  • Szejtli József
    • 1
  1. 1.Chinoin Chemical and Pharmaceutical WorksBudapestHungary
  2. 2.Faculty of Pharmaceutical SciencesHoshi UniversityTokyoJapan
  3. 3.Department of Chemical TechnologyEötvös L. UniversityBudapestHungary

Personalised recommendations