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Prostaglandins and their cyclodextrin complexes

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Abstract

Generally, prostaglandins (PG) are unstable and insoluble in water, though they exhibit strong biological activities in minute amount. The most difficult problem in developing PG preparations is how to stabilize and solubilize PG without loss of their activities. We have successfully developed the pharmaceutical preparations contaning PG complexes with cyclodextrins (CD). These preparations are already on the market, namely PGE2 ·β-CD Tablet and PGE1 ·α-CD Injection. Moreover, PG and PGI2 derivatives are now under development as a form of CD complex.

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Authors and Affiliations

  1. Research Institute Sakurai, Ono Pharmaceutical Co., Ltd., Shimamoto-cho, 618, Mishima, Osaka, Japan

    Kohji Inaba & Tohru Wakuda

  2. Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1, Oe-honmachi, 862, Kumamoto, Japan

    Kaneto Uekama

Authors
  1. Kohji Inaba
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  2. Tohru Wakuda
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  3. Kaneto Uekama
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Inaba, K., Wakuda, T. & Uekama, K. Prostaglandins and their cyclodextrin complexes. Journal of Inclusion Phenomena 2, 467–474 (1984). https://doi.org/10.1007/BF00662213

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  • DOI: https://doi.org/10.1007/BF00662213

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