Archives of oto-rhino-laryngology

, Volume 232, Issue 1, pp 43–55 | Cite as

Ototoxicity or teratogenicity

An analysis of drug-induced effects on the early development of the mammalian otocyst
  • M. Anniko
  • H. Nordemar


The 13th gestational day inner ear (otocyst stage) is particularly vulnerable to toxic influence from the environment during its further development. Ethacrynic acid in a concentration of 1 and 10 μg/ml caused complete arrest in development, and this was not overcome when withdrawing the drug after in vitro exposure to ethacrynic acid during 3 days. Gentamicin exposure at 1 and 10 μg/ml caused dysmorphogenesis but did not inhibit cytodifferentiation which, however, often was poor. Higher concentrations of gentamicin (100 μg/ml) had a more generalized toxic effect not only on epithelial but also on mesenchymal tissue.

Key words

Otocyst Embryonic Development In vitro Ototoxicity Teratogenicity Dysmorphogenesis Gentamicin Ethacrynic acid Inner ear Mammalian 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • M. Anniko
    • 1
  • H. Nordemar
    • 1
  1. 1.Department of OtorhinolaryngologyKarolinska sjukhuset and King Gustaf V Research Institute, Karolinska InstituteStockholmSweden

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