Journal of comparative physiology

, Volume 125, Issue 4, pp 327–334 | Cite as

Gradual increase in the electrical excitability of crayfish slow muscle fibers produced by anoxia or uncouplers of oxidative phosphorylation

  • William MoodyJr.


The electrical properties of crayfish (Procambarus clarkii) tonic flexor muscle fibers have been studied after exposure to anoxia or treatment with uncouplers of oxidative phosphorylation. These fibers do not normally generate action potentials; after anoxia, or treatment with any of three uncouplers (dinitrophenol, dicoumarol, CCCP), they gradually develop the ability to generate action potentials over the course of several hours. This change in excitability is not accompanied by any change in fiber resting potential or input resistance. The time course of uncoupler action is strongly temperature-dependent; it is speeded in fibers treated with cyanide, and slowed in fibers treated with iodoacetate. The possibility that the increase in excitability is caused by a decrease in the internal pH of the fibers is discussed.


Muscle Fiber Cyanide Electrical Property Gradual Increase Oxidative Phosphorylation 



carbonyl cyanide-m-chlorophenylhydra-zone




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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • William MoodyJr.
    • 1
  1. 1.Department of Biological SciencesStanford UniversityStanfordUSA

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