Colloid and Polymer Science

, Volume 274, Issue 9, pp 819–825 | Cite as

Thermodynamic properties of dilution of chondroitin 4-sulfate having tetraalkylammonium counterions

  • H. Tsuge
  • H. Kishimoto
  • M. Yonese
Original Contribution


The dilution enthalpies,ΔdilH, of tetraalkylammonium chondroitin 4-sulfate (R4NChSA) and polyacrylate (R4NPAA) having methyl (Me), ethyl (Et), propyl (Pr) and butyl (Bu) as alkyl groups (R) were measured to elucidate the effects of hydrophobic counterions. TheΔdilH of R4NChS-A and R4NPAA were negative (exothermic) and decreased as the carbon number of tetraalkylammonium cation (R4N+) increased. These results were found to possess the same effects onΔdilH as these of bromides. The non-electrostatic terms of dilution enthalpiesΔdilHn of R4NChS and R4NPAA were evaluated by using the electrostatic terms ofΔdilH obtained from Manning's theory. TheΔdilHn of R4NChS-A and R4NPAA decreased, i.e., their exothermic tendencies increased as the carbon number of R4N+ increased, and the rate of decrease of the R4NPAA was more than that of the R4NChS-A. These results are discussed in relation to the increase of the hydrated water structure around R4N+ on dilution.

Key words

Chondroitin sulfate tetraalkylammonium counterion dilution enthalpy thermodynamic properties polyacrylate 


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Copyright information

© Steinkopff Verlag 1996

Authors and Affiliations

  • H. Tsuge
    • 1
  • H. Kishimoto
    • 2
  • M. Yonese
    • 2
  1. 1.Pharmaceutical Formulation Research LaboratoryDaiichi Pharmaceutical Co., LtdTokyoJapan
  2. 2.Faculty of Pharmaceutical SciencesNagoya City UniversityNagoyaJapan

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