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Effect of corticosterone and triiodothyronine on (Na++K+)-adenosine triphosphatase activity in rat submandibular gland

  • Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands
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Abstract

The present study concerns the effect of glucocorticoids and triiodothyronine (T3) on rat salivary (Na++K+)-adenosine triphosphatase (NaK-ATPase). The results indicate that corticosterone increases submandibular gland NaK-ATPase activity with a single dose of hormone and with two daily doses on three successive days. Multiple injections of dexamethasone also increases submandibular and sublingual gland NaK-ATPase activity. The effect of glucocorticoids on salivary NaK-ATPase is selective since Mg-ATPase shows no significant differences under different steroidal states. We subsequently investigate the possibility of interaction between the effects of corticosterone and triiodothyronine on submandibular gland NaK-ATPase activity. Our studies indicate that each of these hormones increases NaK-ATPase activity in the absence of the other.

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Authors and Affiliations

  1. Department of Physiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA

    Marisa S. Bartolomei, Laura E. Klein, Paul Hsiao & Chu S. Lo

Authors
  1. Marisa S. Bartolomei
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  2. Laura E. Klein
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  3. Paul Hsiao
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  4. Chu S. Lo
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Additional information

This study was supported by NIH grant (AM28590) and USUHS Grant CO7623

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Bartolomei, M.S., Klein, L.E., Hsiao, P. et al. Effect of corticosterone and triiodothyronine on (Na++K+)-adenosine triphosphatase activity in rat submandibular gland. Pflugers Arch. 399, 255–258 (1983). https://doi.org/10.1007/BF00652748

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  • DOI: https://doi.org/10.1007/BF00652748

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