Abstract
Lithium chloride and rubidium chloride were tested under conditions in which the effects of their chronic administration on aversively-controlled behavior could be assessed. Lithium attenuated shock-induced suppression of open-field activity when that suppression was under the control of mild or moderate stimulus parameters, but had no effect on the suppression produced by the presence of shock itself. Rubidium, on the other hand, increased shock-induced suppression under all conditions. When shock was removed and extinction of the activity suppression was investigated, lithium subjects failed to return to their original baseline activity levels, while subjects receiving rubidium recovered baselines in a manner indistinguishable from that observed in control animals.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bernstein JG (1984) Clinical psychopharmacology (2nd ed.). John Wright · PSG Inc, Boston Bristol London
Eichelman B, Thoa NB, Perez-Cruet J (1973) Alkali metal cations: Effects on aggression and adrenal enzymes. Pharmacol Biochem Behav 1:121–123
Fieve RR, Meltzer HL (1978) Lithium prophylaxis and experimental rubidium therapy in affective disorders. In: Iversen LL, Iversen SD, Snyder SH (eds.) Handbook of psychopharmacology, Vol 14. Affective disorders: Drug actions in animals. Plenum Press, New York London, pp 327–369
Hines G, Poling TH (1984) Lithium effects on active and passive avoidance behavior in the rat. Psychopharmacology 82:78–82
Johnson FN (1972a) Chlorpromazine and lithium (Effects on stimulus significance). Dis Nerv Syst 33:235–241
Johnson FN (1972b) Effects of alkali metal chlorides on activity in rats. Nature 238:333–334
Johnson FN (1976) The effects of lithium chloride on one-trial passive avoidance learning in rats. Br J Pharmacol 56:87–91
Johnson FN, Barker GH (1972) Effects of lithium chloride on learned responses: Acquisition, retention, and expression. Dis Nerv Syst 33:664–666
Johnson FN (1984) The Psychopharmacology of lithium. MacMillan Press London
Johnson FN, Wormington S (1972) Effects of lithium on rearing activity in rats. Nature 235:159–160
Katz RJ, Carroll BJ (1977) Effects of chronic lithium and rubidium administration upon experimentally induced conflict behavior. Prog Neuropsychopharmacol 1:285–288
Maffii G (1959) The secondary conditioned response of rats and the effects of some psychopharmacological agents. J Pharm Pharmacol 11:129–139
Meltzer HL, Taylor RM, Platman SR, Fieve RR (1969) Rubidium: A potential modifier of affect and behavior. Nature 233:321–322
Platman SR (1970) A comparison of lithium carbonate and chlorpromazine in mania. Am J Psychiatry 127:351–353
Sheard MH (1970) Effect of lithium on foot shock aggression in rats. Nature 228:284–285
Smith DF (1975) Biogenic amines and the effect of short-term lithium administration on open field activity in rats. Psychopharmacology 41:295–300
Spring GK (1971) Some current thoughts on lithium carbonate in manic-depressive illness based on a double-blind comparison with chlorpromazine. Psychosomatics 12:336–340
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hines, G. Effects of lithium and rubidium on shock-induced changes in open-field activity. Psychopharmacologia 88, 209–212 (1986). https://doi.org/10.1007/BF00652242
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00652242