, Volume 88, Issue 2, pp 141–146 | Cite as

Central noradrenaline depletion antagonizes aspects ofd-amphetamine-induced hyperactivity in the rat

  • Trevor Archer
  • Anders Fredriksson
  • Gösta Jonsson
  • Tommy Lewander
  • Abdul K. Mohammed
  • Svante B. Ross
  • Ulf Söderberg
Original Investigations


The effects of noradrenaline (NA) depletion upon amphetamine-induced hyperactivity were examined in five experiments. Central NA depletion via either systemic DSP4 or neonatal 6-OHDA antagonised the amphetamine-induced (2 mg/kg SC) increase in rearing behaviour, whereas lesions of the dorsal noradrenergic bundle using 6-hydroxydopamine antagonised the increase in locomotor activity. Peripheral NA depletion following systemic 6-hydroxydopamine to adult rats did not cause any changes in motor activity after acute amphetamine administration. Desipramine, the selective NA uptake inhibitor, blocked the effects of DSP4 upon amphetamine-induced rearing. NA depletion antagonised hyperactivity produced by the 2 mg/kg dose of amphetamine, but not the hyperactivity (rearing or locomotion) effects of amphetamine at 1, 4 or 8 mg/kg.

Key words

NA depletion d-Amphetamine DSP4 Neonatal 6-OHDA Adult 6-OHDA Dorsal mundle 6-OHDA DMI Hyperactivity Rearing Locomotion Dose Rat 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Trevor Archer
    • 1
  • Anders Fredriksson
    • 2
  • Gösta Jonsson
    • 3
  • Tommy Lewander
    • 1
  • Abdul K. Mohammed
    • 2
  • Svante B. Ross
    • 1
  • Ulf Söderberg
    • 2
  1. 1.R & D LaboratoriesAstra Läkemedel ABSödertäljeSweden
  2. 2.Neurophysiology Laboratory and Psychiatric Research CenterUller»kers SjukhusUppsalaSweden
  3. 3.Dept. of HistologyKarolinska InstitutetStockholmSweden

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