Abstract
Enthalpies of dilution of N-acetyl amides of sarcosine and N-methyl-L-alanine dissolved in N,N-dimethylformamide have been measured calorimetrically at 25°C. The enthalpic pairwise interaction coefficients calculated there from are negative, indicating a energetically favorable interaction. The results were used to make a comparison with other peptides with regard to the methylation of amide groups. Substituting a primary amide hydrogen by a methyl group gives a smaller positive change of the pairwise interaction coefficient than substituting a secondary amide hydrogen.
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Sijpkes, A.H., Somsen, G. Enthalpies of interaction of N-acetyl amides of sarcosine and N-methyl-L-alanine dissolved in N,N-dimethylformamide at 25°C. J Solution Chem 20, 445–453 (1991). https://doi.org/10.1007/BF00650769
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DOI: https://doi.org/10.1007/BF00650769