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Effect of urethane (ethyl carbamate) on the mitosis of phytohaemagglutinin stimulated human lymphocytesin vitro

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Summary

The action of urethane at concentrations between 10−1 and 10−8 M on the rate of mitosis of phytohaemagglutinin-stimulated human lymphocytes in culture has been investigated. At 10−1M urethane is cytotoxic, at all other concentrations tested it has some inhibitory activity except at 10−5M and 10−6M where it stimulates mitosis. These results are discussed in relation to previously reported data and compared with the action of hydroxyurea in the same system.

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Authors and Affiliations

  1. University Department of Medical Genetics, The Royal Infirmary, Manchester, UK

    J. Timson

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  1. J. Timson
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I wish to thank the Smith Kline and French Foundation for financial support and Mrs. B. Haynes and Miss C. Watson for technical assistance.

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Timson, J. Effect of urethane (ethyl carbamate) on the mitosis of phytohaemagglutinin stimulated human lymphocytesin vitro . W. Roux' Archiv f. Entwicklungsmechanik 165, 174–176 (1970). https://doi.org/10.1007/BF00650145

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  • DOI: https://doi.org/10.1007/BF00650145

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