Journal of Solution Chemistry

, Volume 18, Issue 2, pp 131–142 | Cite as

Excess enthalpies and apparent molar volumes of some N-methyl substituted amino acids in aqueous solutions

  • J. F. Reading
  • P. A. Carlisle
  • G. R. Hedwig
  • I. D. Watson


The excess enthalpies and limiting partial molar volumes at 25°C for aqueous solutions of N-methyl glycine, N-methyl alanine, and N-methyl serine are reported and compared with the same properties for the parent amino acids. For each N-methyl derivative the enthalpic contribution to the pairwise interaction is less favorable than that for the parent amino acid. The contribution of the N-methyl substituent to V 2 0 is similar for each amino acid, and is about 2 cm3-mol−1 greater than for a methyl substituent on the α-carbon. These observations have been rationalized in terms of the likely solute-solvent interactions. In addition a rigid particle model is used with the volume data to examine solute-solvent interactions.

Key words

Enthalpies of dilution density partial molar volume N-methyl amino acid aqueous solution 


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • J. F. Reading
    • 1
  • P. A. Carlisle
    • 1
  • G. R. Hedwig
    • 1
  • I. D. Watson
    • 1
  1. 1.Department of Chemistry and BiochemistryMassey UniversityPalmerston NorthNew Zealand

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