Journal of Solution Chemistry

, Volume 22, Issue 11, pp 975–981 | Cite as

Thermochemistry of aqueous solutions of alkylated nucleic acid bases. VIII. Enthalpies of hydration of 6-alkyluracils

  • W. Zielenkiewicz
  • A. Zielenkiewicz
  • K. L. Wierzchowski
Article

Abstract

Enthalpies of solution in water ΔH sol o and enthalpies of sublimation ΔH sub o were determined for a number of crystalline derivatives of uracil: 1,6-dimethyluracil (m 2 1,6 Ura), 1,3,6-trimethyluracil (m 3 1,3,6 Ura), 6-ethyl-1,3-dimethyluracil (e6m 2 1,3 Ura), 6-propyl-1,3-dimethyluracil (pr6m 2 1,3 Ura) and 6-butyl-1,3-dimethyluracil (but6m 2 1,3 Ura). Standard enthalpies of hydration ΔH hydr o and standard enthalpies of interaction ΔH int o of the solutes with their hydration shells were calculated. The data obtained show that dependence of ΔH int o on the number of-CH2- groups of n-alkyl chain added upon substitution of diketopyrimidine ring is nonlinear. This finding is discussed in connection with results of X-ray diffraction structure determinations for the crystalline compounds.

Key Words

Enthalpy of solution enthalpy of sublimation enthalpy of hydration alkylated derivatives of uracil 

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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • W. Zielenkiewicz
    • 1
  • A. Zielenkiewicz
    • 1
  • K. L. Wierzchowski
    • 2
  1. 1.Institute of Physical ChemistryPolish Academy of SciencesWarszawaPoland
  2. 2.Institute of Biochemistry and BiophysicsPolish Academy of SciencesWarszawaPoland

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