Abstract
Seven cases of phenylketonuria including a pair of siblings were detected among 451 institutionalized mentally retarded individuals in Kuwait. A further 13 cases from eight Arab families of different nationalities were ascertained among referral cases. The occurrence of phenylketonuria in Kuwait and other Arab countries is discussed in view of the high consanguinity rate and large family size. Our findings stress the need for neonatal screening.
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Abbreviations
- PKU:
-
phenylketonuria
References
Al-Awadi SA, Mousa MA, Naguib KK, Farag TI, Teebi AS, El-Khalifa M, El-Dossary L (1985) Consanguinity among the Kuwaiti population. Clin Genet 27:483–486
Bickel H, Gerrard J, Hickmans EM (1983) Influence of phenylalanine intake on phenylketonuria. Lancet 2:812
Bickel H, Guthrie R, Hamersen G (1980) Neonatal screening for inborn errors of metabolism. Springer, Berlin Heidelberg New York
Carson NAJ, Neill DW (1962) Metabolic abnormalities detected in a survey of mentally backward individuals in Northern Ireland. Arch Dis Child 37:505–513
Cowie V (1951) Phenylpyruvic Oligophrenia. J Ment Sci 97:505
Efron ML, Young D, Moser HW, McCready RA (1964) A sample chromatographic screening test for the detection of disorders of aminoacid metabolism. A technique using whole blood or urine collected on filter paper. N Engl J Med 270:1378
Følling A (1934) Über Ausscheidung von phenylbrenztraubensaure in den Harn als Stoffwechsel anomalie in Verbindung mit imbezillitat. Z Physiol Chem 8:1054–1059
Guthrie R, Susi A (1963) A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants. Pediatrics 32:338
Hassan MM (1964) Phenylketonuria in a Sudanese family. J Trop Pediatr 2:282–284
Harris H (1980) The principles of human biochemical genetics. 3rd edn. Elsevier. North Holland Biomedical Press, p 201
Henderson HE, Goodman R, Schram J, Diamond E, Daniel A (1981) Biochemical screening for inherited metabolic disorders in the mentally retarded. S Afr Med J 19:731–733
Jervis GA (1953) Phenylphyruvic Oligophrenia (Phenylketonuria). Res Publ Assoc Nerv Ment Dis 33:259
Kuwait census (1985) Ministry of Planning, Kuwait
McCready RA (1974) Admissions of phenylketonuric patients to residential institutions before and after screening programs of the newborn infant. J Pediatr 58:383–385
Salam M (1963) Phenylketonuria in a child from the Middle East. AM J Dis Child 105:102
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Teebi, A.S., Al-Awadi, S.A., Farag, T.I. et al. Phenylketonuria in Kuwait and Arab countries. Eur J Pediatr 146, 59–60 (1987). https://doi.org/10.1007/BF00647286
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DOI: https://doi.org/10.1007/BF00647286