Abstract
Nuclear-magnetic-relaxation studies of a range of aqueous mono- and disaccharide solutions are reported. These include17O relaxation of solvent and1H,2H,13C, and17O relaxation of various solutes. The limitations of nuclear-magnetic relaxation for providing direct indications of solvent motions or extents of hydration of these sugars are outlined. In contrast to the solvent studies, the motional properties of the solutes themselves have been reasonably well defined, with1H,2H, and13C studies of the sugar ring C−H groups all indicating very similar rotational correlation times. Shorter correlation times estimated for the −CH2OH and −OH side chains, implying that internal motions make a significant contribution to the relaxation of these groups. Differences in reorientation rates of pentose monosaccharides, hexose monosaccharides, and disaccharides are discussed in terms of molecular size and solvent interactions. In every case examined, the solute NMR rotational correlation time is in serious disagreement with that expected from previous dielectric-relaxation studies. Some of the implications of this discrepancy are considered.
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Suggett, A., Ablett, S. & Lillford, P.J. Molecular motion and interactions in aqueous carbohydrate solutions. II. Nuclear-magnetic-relaxation studies. J Solution Chem 5, 17–31 (1976). https://doi.org/10.1007/BF00647178
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DOI: https://doi.org/10.1007/BF00647178