Abstract
The apparent enthalpy, free energy and entropy of transfer from aqueous buffer (pH 7) to water-saturated octanol were determined for the aliphatic alcohols methanol to octanol using an isoperibol flow-calorimeter. For the higher homologues, a linear relationship between enthalpy and free energy change is found indicating an enthalpy-entropy compensation effect. The thermodynamics of transfer were rationalized in terms of the thermodynamics of solvation in the separate phases, including water itself as a solute. The role of water as a cosolvent in the octanol phase is discussed.
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Riebesehl, W., Tomlinson, E. Thermodynamics of non-electrolyte transfer between octanol and water. J Solution Chem 15, 141–150 (1986). https://doi.org/10.1007/BF00646285
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DOI: https://doi.org/10.1007/BF00646285