Determination of nanogram quantities of diphenhydramine and orphenadrine in human plasma using gas-liquid chromatography
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A method is described for the assay of nanogram quantities of diphenhydramine and orphenadrine in human plasma. The procedure employs gas-liquid chromatography and a high sensitivity nitrogen detector. It has been used to assay diphenhydramine in plasma after oral administration of therapeutic doses.
Key wordsDiphenhydramine orphenadrine gas-liquid chromatography N-selective detector pharmacokinetics
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