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European Journal of Clinical Pharmacology

, Volume 6, Issue 4, pp 268–270 | Cite as

Determination of nanogram quantities of diphenhydramine and orphenadrine in human plasma using gas-liquid chromatography

  • W. Bilzer
  • U. Gundert-Remy
Originals

Summary

A method is described for the assay of nanogram quantities of diphenhydramine and orphenadrine in human plasma. The procedure employs gas-liquid chromatography and a high sensitivity nitrogen detector. It has been used to assay diphenhydramine in plasma after oral administration of therapeutic doses.

Key words

Diphenhydramine orphenadrine gas-liquid chromatography N-selective detector pharmacokinetics 

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References

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    Glazko, A.J., Dill, W.A., Fransway, R.L.: Fed. Proc.21, 269 (1962)Google Scholar
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    Dill, W.A., Glazko, A.J.: Personal communication, Research Laboratories, Parke-Davis Inc. Ann Arbor, MichiganGoogle Scholar
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    McGavack, T.H., Drekter, I.J., Schutzer, S., Heisler, A.: J. Allergy19, 251 (1948)Google Scholar

Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • W. Bilzer
    • 1
  • U. Gundert-Remy
  1. 1.Abt. f. klin. PharmakologieMed. Universitätsklinik69 HeidelbergFederal Republic of Germany

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