Determination of nanogram quantities of diphenhydramine and orphenadrine in human plasma using gas-liquid chromatography
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A method is described for the assay of nanogram quantities of diphenhydramine and orphenadrine in human plasma. The procedure employs gas-liquid chromatography and a high sensitivity nitrogen detector. It has been used to assay diphenhydramine in plasma after oral administration of therapeutic doses.
Key wordsDiphenhydramine orphenadrine gas-liquid chromatography N-selective detector pharmacokinetics
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- 1.Glazko, A.J., Dill, W.A., Fransway, R.L.: Fed. Proc.21, 269 (1962)Google Scholar
- 2.Dill, W.A., Glazko, A.J.: Personal communication, Research Laboratories, Parke-Davis Inc. Ann Arbor, MichiganGoogle Scholar
- 3.McGavack, T.H., Drekter, I.J., Schutzer, S., Heisler, A.: J. Allergy19, 251 (1948)Google Scholar