Abstract
The solubilities of adenine in water, thymine in methanol, and uracil in methanol were determined over the temperature range 15–40°C. From these and previously reported data the thermodynamic functions for the transfer of the solute from water to methanol were calculated. The differences in transfer functions for uracil and thymine are due to hydrophobic hydration of the methyl group of thymine.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. Ben-Naim,Hydrophobic Interactions, (Plenum Press, New York, 1980), p. 5.
J. Alvarez and R. Biltonen,Biopolymers 12, 1815 (1973).
R. L. Scruggs, E. K. Achter, and P. D. Ross,Biopolymers 11, 1961 (1972).
J. K. Ahmed, G. A. W. Derwish, and F. I. Kanbour,J. Solution Chem. 10, 343 (1981).
J. N. Spencer, S. W. Barton, K. A. Smith, W. S. Wolbach, J. F. Powell, M. R. Kirshenbaum, D. W. Firth, E. M. Harris, and T. A. Judge, to be published.
T. T. Herskovits and J. P. Harrington,Biochemistry 11, 4800 (1972).
J. N. Spencer, S. W. Barton, K. A. Smith, W. S. Wolbach, J. F. Powell, M. R. Kirshenbaum, and D. W. Firth,Can. J. Chem. 61, 194 (1983).
P. J. Rossky and M. Karplus,J. Am. Chem. Soc. 101, 1913 (1979).
C. Tanford,The Hydrophobic Effect, (Wiley, New York, 1979), pp. 24–25.
G. C. Pimentel and A. L. McClellan,Ann. Rev. Phys. Chem. 22, 347 (1971).
J. N. Spencer, E. S. Holmboe, M. R. Kirshenbaum, S. W. Barton, K. A. Smith, W. S. Wolbach, J. F. Powell, and C. Chorazy,Can. J. Chem. 60, 1183 (1982).
J. N. Spencer, J. E. Gleim, C. H. Blevins, R. C. Garrett, and F. J. Mayer,J. Phys. Chem. 83, 1249 (1979).
C. Tanford,J. Am. Chem. Soc. 84, 4240 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Spencer, J.N., Judge, T.A. Hydrophobic hydration of thymine. J Solution Chem 12, 847–853 (1983). https://doi.org/10.1007/BF00643924
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00643924