Summary
A hypertriploid ascitic tumour with a stem-line of 68 chromosomes was maintained in the NMRI mouse over a period of six years and after 270 transplants. The analysis at three successive dates (1963, 1966 after 135 transplants, and 1969 after 270) showed no change in the stem-line value; a slight progressive increase in the frequency of cell elements belonging to the stem-line; was no change in aneuploidy margins in relation to the stem; no change of the metacentric marker chromosome, either in structure or in frequency; the minute chromosomes were present everywhere, but their number per cell is subject to fluctuations in time; no new markers appeared.
Zusammenfassung
Ein hypertriploider Ascitestumor mit einer Stammlinie von 68 Chromosomen wurde in NMRI-Mäusen 6 Jahre lang mit 270 Transplantationen erhalten. Die Untersuchung zu drei Zeitpunkten (1963, 1966 nach 135 Transplantationen und 1969 nach 270 Transplantationen) ergab: kein Wechsel in der Stammlinie (68 Chromosomen); eine gering fortschreitende Häufigkeitszunahme der Zellen der Stammlinie; keine Änderung in der Ausbreitung der Aneuploidie um die Stammlinie; keine Änderung des metazentrischen Marker-Chromosomes hinsichtlich Struktur und Häufigkeit; kleine Chromosomen waren überall vorhanden, doch war ihre Zahl pro Zelle Schwankungen in zeitlicher Hinsicht unterworfen; neue Marker-Chromosomen traten nicht auf.
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Nombela, J.J.A., Murcia, C.R. Cytogenetic stability of an ascitic tumour “T.A.H.L.M.68” in the mouse. Z Krebs-forsch 75, 262–268 (1971). https://doi.org/10.1007/BF00641957
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DOI: https://doi.org/10.1007/BF00641957