Annals of Hematology

, Volume 72, Issue 2, pp 93–95 | Cite as

Thromboembolism in a patient with transient eosinophilia

  • H. Yamamoto Mukai
  • H. Ninomiya
  • S. Mitsuhashi
  • Y. Hasegawa
  • T. Nagasawa
  • T. Abe
Case Report

Abstract

We report here a case of thromboembolism occurring in a 29-year-old woman with transient eosinophilia. Eosinophilia for at least 11 days was followed by pulmonary embolism. Both reperfusion of pulmonary arteries and disappearance of deep vein thrombi were obtained by treatment with urokinase, tissue plasminogen activator, and heparin. Although the causes of eosinophilia were not specified, we suggested a causative correlation of elevated serum levels of eosinophil granule proteins with the development of thromboembolism.

Key words

Eosinophil Eosinophilia Major basic protein Thromboembolism Thrombomodulin 

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References

  1. 1.
    Chusid MJ, Dale DC, West BC, Wolfe SM (1975) The hypereosinophilic syndrome. Medicine 54:1–27Google Scholar
  2. 2.
    Crofton JW, Livingstone JL, Oswald NC, Roberts ATU (1952) Pulmonary eosinophilia. Thorax 7:1–35Google Scholar
  3. 3.
    Dählback B, Carlsson M, Svensson PJ (1993) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 91:1396–1400Google Scholar
  4. 4.
    Elouaer-Blanc L, Zafrani ES, Farcet JP, Girardin MFSM, Mathieu D, Dhumeaux D (1985) Hepatic vein obstruction in idiopathic hypereosinophilic syndrome. Arch Intern Med 145:751–753Google Scholar
  5. 5.
    Esmon CT, Owen WG (1981) Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci USA 78:2249–2252Google Scholar
  6. 6.
    Fauci AS, Harley JB, Roberts WC, Ferrans VJ, Gralnick HR, Bjornson BH (1982) The idiopathic hypereosinophilic syndrome. Ann Intern Med 68:78–92Google Scholar
  7. 7.
    Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C (1981) Deficiency of protein C in congenital thrombotic disease. J Clin Invest 68:1370–1373Google Scholar
  8. 8.
    Liebow A, Carrington CB (1969) The eosinophilic pneumonia. Medicine 48:251–285Google Scholar
  9. 9.
    Mukai HY, Ninomiya H, Ohtani K, Nagasawa T, Abe T (1995) Major basic protein binding to thrombomodulin potentially contributes to the thrombosis in patients with eosinophilia. Br J Haematol 90:892–899Google Scholar
  10. 10.
    Ratnoff OD, Gleich GJ, Shurin SB, Kazura J, Everson B, Embury P (1993) Inhibition of the activation of Hageman factor (Factor XII) by eosinophils and eosinophilic constituents. Am J Hematol 42:138–145Google Scholar
  11. 11.
    Reeder WH, Goodrich BE (1952) Pulmonary infiltration with eosinophilia (PIE syndrome). Ann Intern Med 36:1217–1240Google Scholar
  12. 12.
    Suenaga N, Hayashi F, Miyauchi N, Nakamura H, Kitada O, Sugita M, Uematsu K, Kitaichi M (1991) A case of hypereosinophilic syndrome associated with pulmonary infarction and hepatic vein obstruction (Budd-Chiari syndrome). Jpn J Thorac Dis 29:239–244Google Scholar
  13. 13.
    Takai K, Sanada M (1991) Hypereosinophilic syndrome evolving to acute lymphoblastic leukemia. Int J Hematol 54:231–239Google Scholar
  14. 14.
    Venge P, Dahl R, Hallgren R (1979) Enhancement of factor XII-dependent reactions by eosinophil cationic protein. Thromb Res 14:641–649Google Scholar
  15. 15.
    Weller PF, Bubley GJ (1994) The idiopathic hypereosinophilic syndrome. Blood 83:2759–2779Google Scholar
  16. 16.
    Yamamoto H, Ninomiya H, Yoshimatsu K, Uchiyama Y, Shibasaki M, Enokihara H, Tachibana S, Abe T (1994) Serum levels of major basic protein in patients with or without eosi nophilia: measurement by enzyme-linked immunosorbent assay. Br J Haematol 86:490–495Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • H. Yamamoto Mukai
    • 1
  • H. Ninomiya
    • 1
  • S. Mitsuhashi
    • 1
  • Y. Hasegawa
    • 1
  • T. Nagasawa
    • 1
  • T. Abe
    • 1
  1. 1.Division of Hematology, Institute of Clinical MedicineUniversity of TsukubaTsukuba-shi, Ibaraki-ken 305Japan

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