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Food deprivation decreases the exertion-induced acid hydrolase response in mouse skeletal muscle

  • Markku Kihlström
  • Antero Salminen
  • Veikko Vihko
Article

Summary

Strenuous prolonged running causes muscle fibre necrosis in skeletal muscles. The muscle injury is associated with inflammation and a strong increase in the total activities of certain acid hydrolases a few days after exertion. The activity changes of acid hydrolases quantitatively well reflect the severity of histopathological changes during the myopathy (for review see Salminen, Acta Physiol Scand [Suppl 539] 1985). In this study male NMRI-mice were exposed to a protocol of fasting and refeeding together with or without a 6 h run on a treadmill at 13.5 m · min−1 The animals were killed 4 days after the exercise and samples from the red part of quadriceps femoris were analyzed for arylsulfatase (ASase) and β-glucuronidase (GUase) activities. Starvation protocols did not affect ASase or GUase. Running caused a 3.2-fold increase in ASase and a 5.1-fold increase in GUase. If mice were exercised in the fasted condition a normal exercise response occurred in both activities, but when mice were exercised 2 days after the finish of fasting the exercise response was greatly diminished. Thus food deprivation followed by 2 days refeeding induces a protection against exercise myopathy in mice. The protection greatly resembles that induced by regular endurance training preceding strenuous prolonged exertion.

Key words

Exertion Lysosomes Inflammation Fasting Protection 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Markku Kihlström
    • 1
  • Antero Salminen
    • 1
  • Veikko Vihko
    • 2
  1. 1.Department of Cell BiologyUniversity of JyväskyläJyväskyläFinland
  2. 2.Research Unit for Sports and Physical FitnessJyväskyläFinland

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