European Journal of Nuclear Medicine

, Volume 12, Issue 1, pp 41–46 | Cite as

Chemical, radiochemical, and radionuclide purity of eluates from different commercial fission99Mo/99mTc generators

  • Andreas Hammermaier
  • Ernst Reich
  • Werner Bögl
Article

Abstract

Seven99Mo/99mTc generators (using fission99Mo) obtained from seven different manufactures were studied in 1984 and 1985 to test the quality of the eluates. We present the findings concerning the elution efficiency, radionuclide purity,99Mo breakthrough, radiochemical purity, pH, and aluminium content of the eluates. One generator was overloaded with99Mo by about 40%, while one generator had99mTc yields of only about 80%. The eluates generally (although with some exceptions) exhibited a high and satisfactory radionuclidic purity and good radiochemical purity. The low-level determination of99Mo break-through using a commercially available dose calibrator with a99Mo assay shiled indicated a misleadingly high99Mo content. All of the eluates had pH values of between 5.0 and 5.5, and the aluminium content was always below the detection limit of 1 μg per milliliter of eluate. The generators performed well and proved their capability of functioning as reliable sources of sodium pertechnetate Tc99m. In all cases, the pertechnetate produced met the requirements of the European Pharmacopeia.

Key words

Quality control Radioisotope generators 99Mo 99mTc 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Andreas Hammermaier
    • 1
  • Ernst Reich
    • 1
  • Werner Bögl
    • 1
  1. 1.Fachgebiet E I 3Institut für Strahlenhygiene des BundesgesundheitsamtesNeuherbergFederal Republic of Germany

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