European Journal of Nuclear Medicine

, Volume 12, Issue 1, pp 21–26 | Cite as

Brain ischemia and infarction positively visualized by pyruvate-1-11C using positron-emission tomography

  • Toshihiko Hara
  • Fuji Yokoi
  • Masaaki Iio


We describe positron-emission tomography (PET) scintigraphic findings obtained using pyruvate-1-11C in eight patients with cerebral ischemic hypoxia or infarction. The extraction of11C by brain tissue from blood after an i.v. injection of11C-pyruvate was very rapid, being almost complete after a single circulatory passage. Most ischemic lesions were found to be more or less deficient with regard to11C-extraction capacity. With time, however, the ratio of11C in ischemic tissue to that in normal tissue was inverted, and the ischemic lesion appeared as a ‘hot’ area in the scintigram. Very old infarcts did not exhibit this phenomenon. These observations indicate the usefulness of an11C-pyruvate PET scan for the diagnosis of therapeutically restorable brain damage.

Key words

Pyruvate-1-11Ischemia PET 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Toshihiko Hara
    • 1
  • Fuji Yokoi
    • 2
  • Masaaki Iio
    • 1
  1. 1.National Nakano Chest HospitalTokyoJapan
  2. 2.National Center for Nervous, Mental and Muscular DisordersKodaira-City, TokyoJapan

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