European Journal of Clinical Pharmacology

, Volume 36, Issue 6, pp 625–627 | Cite as

Sustained-release and instant-release verapamil in treatment of angina pectoris

  • C. M. Jespersen
  • N. A. Klitgaard
  • H. Nielsen
  • J. Fischer Hansen
Short Communications


The efficacy of a sustained-release preparation of verapamil (verapamil-IR) has been compared with that of a conventional instant-release formulation (verapamil-IR) in 10 patients with stable angina pectoris treated for 3 weeks with both preparations.

The diurnal serum concentrations of verapamil and norverapamil did not differ significantly during treatment with verapamil-IR 120 mg t.i.d. and verapamil-SR 360 mg once daily, but verapamil-SR 240 mg produced significantly lower serum concentrations. The differences did not affect the exercise capacity or the occurrence of ST-segment depression during maximal exercise.

Verapamil-SR was well tolerated. A multiple instant-release dosage regime can now be replaced by once daily administration of the sustained-release preparation.

Key words

verapamil angina pectoris sustained-release formulations serum levels 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • C. M. Jespersen
    • 1
  • N. A. Klitgaard
    • 2
  • H. Nielsen
    • 1
  • J. Fischer Hansen
    • 1
  1. 1.Medical Department, Division of CardiologyKøbenhavns KommunehospitalCopenhagenDenmark
  2. 2.Department of Clinical ChemistryOdense University HospitalOdenseDenmark

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