Postprandial changes in supine and erect heart rate, systemic blood pressure and plasma noradrenaline and renin activity in normal subjects
- 42 Downloads
The haemodynamic effects of a standard meal were assessed in a balanced cross-over study in eight normal fasting subjects, investigated under conditions applicable to many drug tests.
Both the supine and erect diastolic blood pressure were reduced on average by 10 mmHg over the 4 h following the meal.
The supine systolic pressure was increased on average by 2 mmHg, a difference of no biological relevance. Erect systolic blood pressure was not affected by eating.
Supine heart rate was slightly but significantly increased, but the erect heart rate did not change.
Postprandial plasma renin activity was increased. Venous plasma noradrenaline levels in the supine position were not affected by eating and after standing erect, and immobile for 5 min they were only slightly and not-significantly increased.
A food-induced vasodepressor response combined with baroreceptor resetting is considered to have occurred in this population. The changes had a gradual onset, reaching their maximum about 2 h after eating and they were still evident after 3 h. Eating should be considered as an important potential source of bias in cardiovascular studies.
Key wordshypotension food intake blood pressure normal subjects noradrenaline plasma renin activity
Unable to display preview. Download preview PDF.
- 1.Packer M, Medina N, Yushak M (1985) Hemodynamic changes mimicking a vasodilator drug response in the absence of drug therapy after right heart catheterization in patients with chronic heart failure. Circulation 71: 761–766Google Scholar
- 2.Cornyn JW, Massie BM, Unverferth DV, Leier CV (1986) Hemodynamic changes after meals and placebo treatment in chronic congestive heart failure. Am J Cardiol 57: 238–241Google Scholar
- 3.Grollman A (1929) The effect of ingestion of food on cardiac output, pulse rat, blood pressure and oxygen consumption in man. Am J Physiol 89: 366–370Google Scholar
- 4.Gladstone SA (1935) Cardiac output and renal functions under basal and post-prandial conditions. Arch Intern Med 55: 553–546Google Scholar
- 5.Abramson DI, Fierst SM (1941) Peripheral vascular responses in man during digestion. Am J Physiol 133: 686–693Google Scholar
- 6.Bagatell MS, Heymsfield SB (1984) Effect of meal size on myocardial oxygen requirements: implications for post-myocardial infarction diet. Am J Clin Nutr 39: 321–426Google Scholar
- 7.Fagan TC, Sawyer PR, Gourley LA, Lee JT, Gaffney TE (1986) Postprandial alterations in hemodynamics and blood pressure in normal subjects. Am J Cardiol 58: 636–641Google Scholar
- 8.Burgess CD, Crane J (1986) The comparative effects of digoxin and food alone and in combination in normal males. Eur J Clin Pharmacol 29: 685–689Google Scholar
- 9.Fagan TC, Conrad KA, Mar JH, Nelson L (1986) Effects of meals on hemodynamics: implications for antihypertensive drug studies. Clin Pharmacol Ther 39: 255–260Google Scholar
- 10.Herrick JF, Essex HE, Mann FC, Baldes EJ (1934) The effect of digestion on the blood flow in certain blood vessels of the dog. Am J Physiol 108: 621–628Google Scholar
- 11.Orrego H, Mena I, Baraona E, Palma R (1965) Modifications in hepatic blood flow and portal pressure produced by different diets. Am J Dig Dis 10: 239–248Google Scholar
- 12.Brandt JL, Castleman L, Ruskin HD, Greenwald JJ, Kelly J (1965) The effect of oral protein and glucose feeding on splanchnic blood flow and oxygen utilization in normal and cirrhotic subjects. J Clin Invest 34: 1017–1025Google Scholar
- 13.Norryd C, Denker H, Lunderquist A, Olin T, Tylen U (1975) Superior mesenteric blood flow during digestion in man. Acta Chir Scand 141: 197–202Google Scholar
- 14.Marigold JH, Gilmore IT, Thompson RPH (1981) Effects of a meal on plasma clearance of C14-glycocholic acid and indo cyanine green in man. Clin Sci 61: 325–330Google Scholar
- 15.Svensson CK, Edwards DJ, Mauriello PM, Barde SH, Foster AC, Lanc RA, Middleton E, Lalka D (1983) Effect of food on hepatic blood flow: implications in the “food effect” phenomenon. Clin Pharmacol Ther 34: 316–323Google Scholar
- 16.Ren J, Leithe M, Huss P, Unverferth D, Leier C (1983) The effects of ibopamine on cardiovascular and renal function in normal subjects. Curr Ther Res 34: 667–675Google Scholar
- 17.Eckberg DL (1980) Parasympathetic cardiovascular control in human disease: a critical review of methods and results. Am J Physiol 239: H581-H593Google Scholar
- 18.de Mey C, Enterling D (1986) Assessment of the hemodynamic response to single passive head up tilt by non-invasive methods in normotensive subjects. Methods Find Exp Clin Pharmacol 8: 449–457Google Scholar
- 19.de Mey H, Enterling D (1986) Variant responses to passive upright tilt. Lancet 2: 221Google Scholar
- 20.Spodick DH, Lance VQ (1977) Comparative orthostatic responses: standing vs head-up tilt. Aviat Space Environ Med 48: 432–433Google Scholar
- 21.Hines S, Houston M, Robertson D (1981) The clinical spectrum of autonomic dysfunction. Am J Med 70: 1091–1096Google Scholar
- 22.Lipsitz LA, Nyquist RP, Wei JY, Rowe JW (1983) Postprandial reduction in blood pressure in the elderly. N Engl J Med 309: 81–83Google Scholar
- 23.Robertson D, Wade D, Roberston RM (1981) Postprandial alterations in cardiovascular hemodynamics in autonomic dysfunctional states. Am J Cardiol 48: 1048–1052Google Scholar
- 24.Turnbull CJ, Palmer KT, Taylor BB (1981) Autonomic failure with postprandial hypotension. NZ Med J 93: 6–8Google Scholar
- 25.Brandenberger G, Follenius M, Muzet A, Ehrhart J, Schieber JP (1985) Ultradian oscillations in plasma renin activity: their relationships to meals and sleep stages. J Clin Endocrinol Metab 61: 280–284Google Scholar
- 26.Angeras U, Farnebo LO, Graffner H, Hamberger B, Uvnas-Moberg K, Jarhult J (1982) Effects of food on plasma catecholamine and gastrin levels in patients with duodenal ulcer and normal volunteers. Digestion 25: 205–210Google Scholar
- 27.Knoll E, Mueller FW, Ratge D, Bauersfeld W, Wisser H (1984) Influence of food intake on concentrations of plasma catecholamines and cortisol. J Clin Chem Clin Biochem 22: 597–602Google Scholar