Transition Metal Chemistry

, Volume 11, Issue 4, pp 131–137 | Cite as

Transition metal ion complexes of thiosemicarbazones derived from 2-acetylpyridineN-oxide. I. The 4-methyl derivative

  • Douglas X. West
  • Robert M. Makeever
  • Gozen Ertem
  • John P. Scovill
  • Lewis K. Pannell
Full Papers


TheN-methyl-2-[1-(2-pyridinyl-1-oxide)ethylidene]hydrazinecarbothioamide, HLO4M, has been used to prepare a series of CoIII, NiII and CuII complexes. Species with two deprotonated LO4M ligands, one LO4M and one HLO4M ligand, two HLO4M ligands and one HLO4M ligand with two small anionic ligands have been isolated. The deprotonated LO4M bonds as a tridentate ligandvia theN-oxide oxygen, the imine nitrogen (N1 and the sulphur while the HLO4M ligand coordinates primarily as a bidentate ligandvia only the first two atoms listed above. I.r., electronic, mass and e.s.r. spectra have been used to determine the nature of these complexes. One of the more striking differences between these compounds and those prepared with other thiosemicarbazones of 2-acetylpyridine and 2-acetylpyridineN-oxide is that tetrahedral yellow [Ni(HL)X2] rather than planar brown [NiLX] (X=Cl or Br) solids have been isolated with this ligand. Other differences in the nature of the coordination spheres of the various metal ions occur with this particular ligand when compared to previously studied thiosemicarbazone complexes.


Oxygen Nitrogen Sulphur Coordination Sphere Striking Difference 
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Copyright information

© VCH Verlagsgesellschaft mbH 1986

Authors and Affiliations

  • Douglas X. West
    • 1
  • Robert M. Makeever
    • 1
  • Gozen Ertem
    • 1
  • John P. Scovill
    • 2
  • Lewis K. Pannell
    • 3
  1. 1.Department of ChemistryIllinois State UniversityNormalUSA
  2. 2.Division of Experimental TherapeuticsWalter Reed Army Institute of ResearchWashington, DCUSA
  3. 3.National Institute of Arthritis, Diabetes, Digestive and Kidney DiseasesNational Institutes of HealthBethesdaUSA

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