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Transpulmonary pressure and phrenic activity in early inspiration

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Summary

The direct impact of changes in endtidal transpulmonary pressure (P′ L ) on phrenic (Phr) activity has been investigated in 6 cats anaesthetized with pentobarbital or ketamine. Rapid changes inP′ L were accomplished by steplike changes in tracheal pressure (P tr ), i.e., fromP tr =−12, −6, +6 and +9 cmH2O toP tr =0, and reversely. Phr activity was determined 0.2 and 0.4 s after the onset of Phr activity. This analysis was carried out for a few breaths immediately preceding and following theP tr change, and the results forP tr =0 were used as a reference. Oppositely directed steps inP tr , e.g., fromP tr =0 toP tr =+6 and, reversely, fromP tr =0 toP tr =+6 toP tr =0 toP tr =0, caused equal but opposite changes in Phr activity. Phr activity decreased with increasingP′ P tr =0 toP′ L , and this decrease amounted to 15% and 12% for each cmH2O increase inP′ L at 0.2 and 0.4 s respectively. These results imply that changes inP′ L especially affect Phr activity early in inspiration. The results also show that Phr activity in the initial phase of inspiration strongly depends onP′ L . Inhibition of inspiration facilitatory neurons by slowly adapting stretch receptors may be the kernel of the underlying mechanism of our findings.

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Authors and Affiliations

  1. Department of Medical Physiology, State University Utrecht, Vondellaan 24, 3521, GG Utrecht, The Netherlands

    S. C. M. Luijendijk

  2. Department of Physiology, McGill University, 3655 Drummond Street, H3G 1Y6, Montreal, Quebec, Canada

    G. Kelly & T. Trippenbach

Authors
  1. S. C. M. Luijendijk
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  2. G. Kelly
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  3. T. Trippenbach
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Luijendijk, S.C.M., Kelly, G. & Trippenbach, T. Transpulmonary pressure and phrenic activity in early inspiration. Europ. J. Appl. Physiol. 58, 208–213 (1988). https://doi.org/10.1007/BF00636628

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  • DOI: https://doi.org/10.1007/BF00636628

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