The effect of pindolol, a beta-receptor blocking agent, in heart rate and blood-pressure during submaximal and maximal exercise
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The effect of a new beta-receptor blocking agent, 4-2 (2-hydroxy-3-isopropylaminopropoxy)-indole, pindolol (Viskén®), was investigated in patients with essential hypertension of WHO grades I–II. Maximal and submaximal working capacity tests were done before and during treatment in 30 patients. 15 patients underwent a double-blind cross-over trial with placebo; and a further 15 patients were examined in an open study including a multiscaled working capacity test. The work tests were performed on a bicycle ergometer with increasing loads. The ECG was recorded continuously, and the blood-pressure was measured with a cuff. — In both groups the heart rate and systolic blood-pressure decreased significantly during treatment with Viskén, both at rest and during exercise. The resting and post-exercise diastolic blood-pressures were also significantly reduced after beta-receptor blockade with Viskén. No ECG signs of myocardial ischemia were found. The work capacity tests showed a slight reduction, of about 100 kpm/min, in four patients, whilst three improved their maximal working capacity.
Key wordsbeta-blockade substituted indoles hypertension work capacity clinical trial
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- 1.Bello, C.T., Sevy, R.W., Harakal, C., Hillyer, P.: Relationship between clinical severity of disease and hemodynamic patterns in essential hypertension. Amer. J. Med. Sci.253, 194–208 (1967).Google Scholar
- 2.Johnsson, G., De Guzmann, M., Bergman, H., Sannerstedt, R.: Hemodynamic effect of alprenolol and propranolol at rest and during exercise in hypertensive patients. Pharmacol. Clin.2, 34–39 (1969).Google Scholar
- 3.Levy, J.V.: Cardiovascular effect of prinodolol (LB 46), a potent beta-adrenergic receptor antagonist. J. clin. Pharmacol11, 249–260 (1971).Google Scholar
- 4.Prichard, B.N., Gillam, P.M.: Treatment of hypertension with propranolol. Brit. med. J.1, 7–16 (1969).Google Scholar
- 5.Shinebourne, R., Fleming, J., Hamer, J.: Effects of beta-adrenergic blockade during exercise in hypertensive and ischaemic heart disease. Lancet1967 II, 1217–1220.Google Scholar
- 6.Waal, H.J.: Hypertensive action of propranolol. Clin. Pharmac. Ther.7, 588–598 (1966).Google Scholar