Archives of Gynecology and Obstetrics

, Volume 256, Issue 2, pp 85–88 | Cite as

The relation between depth of trophoblastic invasion and β-HCG levels in tubal pregnancies

  • M. Klein
  • A. Graf
  • H. Kiss
  • K. Czerwenka
  • A. Beck
  • C. Egarter
  • P. Husslein
Originals

Abstract

β-HCG (human chorionic gonadotropin) values of over 2500 I.U./l are associated with higher failure rates for therapy with prostaglandin F2 alpha in tubal pregnancies. The purpose of our study was to ascertain if the 2500 I.U./l limit correlates with histopathology. We therefore compared the pre-operative β-HCG-values and intraluminal and extraluminal trophoblast growth in tubal pregnancy. Purely intraluminal trophoblast was significantly more frequent in patients of group I (β-HCG < 2500 I.U./1), while group II patients (β-HCG > 2500 I.U./l.) almost exclusively had extraluminal growth (P=0.0045). Since the efficacy of prostaglandin F2 alpha therapy depends on intact tubal musculature the correlation of the β-HCG threshold level with histopathologic findings may explain the high failure rate in patients with β-HCG values above 2500 I.U./l.

Key words

Tubal pregnancy Trophoblast growth Serum-β-MG-values 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. Klein
    • 1
  • A. Graf
    • 2
  • H. Kiss
    • 3
  • K. Czerwenka
    • 4
  • A. Beck
    • 1
  • C. Egarter
    • 3
  • P. Husslein
    • 3
  1. 1.Department of GynecologyHanusch-KrankenhausViennaAustria
  2. 2.Department of GynecologyLandeskrankenhaus SalzburgAustria
  3. 3.Department of Obstetrics and GynecologyUniversity of ViennaAustria
  4. 4.Institute for Gynecological PathologyUniversity of ViennaAustria

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