, Volume 99, Issue 1, pp 136–139 | Cite as

Fixed-interval schedules for drug self-administration in the rat

  • William A. Corrigall
  • Kathleen M. Coen
Rapid Communications


The practicality of using second-order fixed-interval schedules in studies of heroin reinforcement with rats was examined. Optimum rates of responding were obtained with a dose of 0.03 mg/kg/infusion and an interval duration of 3 min. In addition, schedules consisting of a only a single interval were shown to be practical, leading to response rates comparable to those obtained with cocaine or food as reinforcer.

Key words

Fixed-interval Self-administration Second-order schedule Heroin Cocaine 


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  1. Corrigall WA (1987) Heroin self-administration: effects of antagonist treatment in lateral hypothalamus. Pharmacol Biochem Behav 27:693–700Google Scholar
  2. Corrigall WA, Vaccarino FJ (1988) Antagonist treatment in nucleus accumbens or periaqueductal grey affects heroin self-administration. Pharmacol Biochem Behav 30:443–450Google Scholar
  3. Corrigall WA, Herling S, Coen KM (1988) Evidence for opioid mechanisms in the behavioral effects of nicotine. Psychopharmacology 96:29–35Google Scholar
  4. Dai S, Corrigall WA, Coen KM, Kalant H (1989) Heroin selfadministration: influence of dose and physical dependence. Pharmacol Biochem Behav 32 (in press)Google Scholar
  5. Dougherty J, Pickens R (1973) Fixed-interval schedules of intravenous cocaine presentation in rats. J Exp Anal Behav 20:111–118Google Scholar
  6. Goeders NE, Smith JE (1983) Cortical dopaminergic involvement in cocaine reinforcement. Science 221:773–775Google Scholar
  7. Goeders NE, Lane JD, Smith JE (1984) Self-administration of methionine enkephalin into the nucleus accumbens. Pharmacol Biochem Behav 20:451–455Google Scholar
  8. Pettit HO, Ettenberg A, Bloom FE, Koob GF (1982) Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology 84:167–173Google Scholar
  9. Roberts DCS, Koob GF (1982) Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats. Pharmacol Biochem Behav 17:901–904Google Scholar
  10. Spealman RD, Goldberg SR (1978) Drug self-administration by laboratory animals: control by schedules of reinforcement. Annu Rev Pharmacol Toxicol 18:313–339Google Scholar
  11. White JM, Ganguzza CC (1985) Effects of nicotine on schedulecontrolled behaviour. Neuropharmacology 24:75–82Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • William A. Corrigall
    • 1
    • 2
  • Kathleen M. Coen
    • 1
  1. 1.Addiction Research FoundationTorontoCanada
  2. 2.Department of PhysiologyUniversity of TorontoTorontoCanada

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