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Archives of Gynecology and Obstetrics

, Volume 256, Issue 1, pp 17–22 | Cite as

Peritoneal fluid volume and steroid hormone concentrations in baboons with and without either spontaneous minimal/mild endometriosis or the luteinized unruptured follicle syndrome

  • T. M. D'Hooghe
  • C. S. Bambra
  • J. Kazungul
  • P. R. Koninckx
Originals

Abstract

This study was performed to document for the first time peritoneal fluid volumes and steroid hormone levels in baboons with and without endometriosis. A laparoscopy was carried out in 19 female baboons (11 with a normal pelvis and 8 with histologically proven spontaneous minimal/mild endometriosis) during 64 cycles in the early luteal phase. Peritoneal fluid was measured and aspirated. The pelvis was examined for evidence of recent ovulation and endometriosis. Peritoneal fluid and serum were assayed for 17beta-estradiol and progesterone. The mean volume of peritoneal fluid and its concentration of 17beta-estradiol and progesterone were 2.6 ml, 679 pmol/l and 64 nmol/1, respectively. No differences were observed between animals with or without either endometriosis or luteinized unruptured follicle syndrome. The peritoneal fluid and serum steroid levels were comparable to those found in women. The results presented are similar to those obtained in women with endometriosis and this suggests that the baboon can be used for the study of this disease.

Key words

Peritoneal fluid Volume Steroids Baboons Endometriosis 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • T. M. D'Hooghe
    • 1
    • 2
  • C. S. Bambra
    • 1
  • J. Kazungul
    • 1
  • P. R. Koninckx
    • 2
  1. 1.Department of Reproduction, Institute of Primate ResearchNational Museums of KenyaNairobiKenya
  2. 2.Department of Obstetrics and GynecologyUniversity Hospital GasthuisbergLeuvenBelgium

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