Abstract
Prostaglandins (PGs) injected into the right lateral brain ventricle (i.v.c.) of the rat increased the sleeping time induced by hexobarbital, chloral hydrate, and ethanol. PGE1 and PGE2 intensified chlorpromazine-induced catalepsy, inhibited amphetamine hyperactivity, and significantly depressed the amphetamine-induced stereotypy. NA concentrations were decreased by PGE1 and PGE2 and were increased by PGF2α. PGF2α increased both 5-HT and 5-HIAA levels in rat brain. “Total” ACh concentrations were increased by PGF1α and PGF2α. PGE1, PGE2, and PGF2α enhanced the turnover of NA, DA, and 5-HT. PGE2 counteracted the decreased activity induced by α-MT and abolished the hypothermic action of α-MT. PGF2α had little effect on the activity of PCPA pretreated rats, whereas the higher doses of PGF2α increased body temperature in these animals.
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Poddubiuk, Z.M., Kleinrok, Z. A comparison of the central actions of prostaglandins A1, E1, E2, F1α, and F2α in the rat. Psychopharmacology 50, 95–102 (1976). https://doi.org/10.1007/BF00634162
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DOI: https://doi.org/10.1007/BF00634162