, Volume 50, Issue 1, pp 89–94 | Cite as

A comparison of the central actions of prostaglandins A1, E1, E2, F, and F in the rat

I. Behavioral, antinociceptive and anticonvulsant actions of intraventricular prostaglandins in the rat
  • Zbigniew M. Poddubiuk
Animal Studies Original Investigations


The effect of prostaglandins (PGs) A1, E1, E2, F, and F administered intraventricularly at doses of 0.02–4.0 μg/rat were studied in some behavioral, antinociceptive and anticonvulsant tests in rats. Exploratory and locomotor activity were decreased by all PGs except A1 and F which had no effect on locomotor activity. All PGs studied, except A1, induced hyperthermia and afforded protection in the ‘hot-plate’ analgesic test and against maximal electroshock seizures.

Key words

Prostaglandins A1, E1, E2, F, F Intraventricular administration Rat Behavior 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Zbigniew M. Poddubiuk
    • 1
  1. 1.Department of PharmacologySchool of MedicineLublinPoland

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