Abstract
Tourette's syndrome patients treated successfully with haloperidol, untreated patients, and healthy controls were studied with tests of temporal discrimination and measures of transmitted information shown previously to be sensitive to brain dysfunction. Untreated patients showed no impairment of temporal processing while those treated with haloperidol showed significant deficit in amount of transmitted information comparable to prior studies of brain syndromes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bruun, R. D., Shapiro, A. K.: Differential diagnosis of Gilles de la Tourette's syndrome. J. nerv. ment. Dis.155, 328–344 (1972)
Crain, P., Goldstone, S., Lhamon, W. T.: Temporal information processing and psychopathology. Percept. mot. Skills44, 219–224 (1975)
Garner, W. R.: Uncertainty and structure as psychological concepts. New York: John Wiley 1962
Goldstone, S., Kirkham, J. E.: The effects of secobarbital and dextroamphetamine upon time judgment: intersensory factors. Psychopharmacology (Berl.)13, 65–73 (1968)
Hibbard, T. R., Migliaccio, J. N., Goldstone, S., Lhamon, W. T.: Temporal information processing by young and senior adults and patients with senile dementia. J. Geront.30, 326–330 (1975)
Locke, S. A.: Temporal discrimination of brief auditory stimuli by schizophrenics, neurologically impaired, and normals. Percept. mot. Skills39, 1111–1120 (1974)
Ribot, T.: The disease of memory (ed. 4). London: Kegan Paul, French, Trubner 1898
Shapiro, A. K., Shapiro, E., Wayne, H. L.: The symptomatology and diagnosis of Gilles de la Tourette's syndrome. J. Amer. Acad. Child Psychiat.12, 702–723 (1973a)
Shapiro, A. K., Shapiro, E., Wayne, H. L.: Treatment of Tourette's syndrome with haloperidol: review of 34 cases. Arch. gen. Psychiat.28, 92–97 (1973b)
Shapiro, A. K., Shapiro, E., Wayne, H. L., Clarkin, J., Bruun, R. D.: Tourette's syndrome: summary of data on 34 patients. Psychosomat. Med.35, 419–435 (1973)
Werry, J. S., Aman, M. G.: Methylphenidate and haloperidol in children: effects on attention, memory, and activity. Arch. gen. Psychiat.32, 790–795 (1975)
Author information
Authors and Affiliations
Additional information
Supported in part by the Grace H. Lineberry Memorial Fund. The authors are indebted to A. K. Shapiro, M.D., E. Shapiro, Ph.D. and R. D. Bruun, M.D. for their assistance, and special gratitude to the patients who participated
Rights and permissions
About this article
Cite this article
Goldstone, S., Lhamon, W.T. The effects of haloperidol upon temporal information processing by patients with Tourette's syndrome. Psychopharmacology 50, 7–10 (1976). https://doi.org/10.1007/BF00634147
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00634147