Summary
In psychiatry the relationship between rating by others and self-rating has been discussed again and again. The question has been raised as to the influence of complete data material (all patients with self-rating and rating by others) on results, in comparison to results where patients without self-rating are not taken into evaluation. This question was answered by conducting a double-blind study which included two pharmacologically active substances (amitriptylinoxide and trazodone) and two sub-samples of patients (patients with rating by others and self-rating, and patients with rating by others alone). The trial was performed in a total of 57 in-patients suffering from endogenous depression (ICD 296.1) who received drug treatment for 21 days. The effect was assessed multi-methodically. While no differences between the two drugs were seen in the sub-sample “self-rating and rating by others”, amitriptylinoxide proved to be superior to trazodone in the sub-sample “rating by others”. On the basis of these findings the use of rating by others and self-rating procedures will be considered.
Similar content being viewed by others
References
AMDP (1983) (Hrsg) Testmanual zum AMDP-System. Verfaßt von U Baumann, RD Stieglitz. Springer, Berlin 1983
Baumann U, Meyer B, Suter U (1974) Formale und inhaltliche Über-prüfung der PND-Skalen. Diagnostica 20:3–21
Baumann U (1976) Methodische Untersuchungen zur Hamilton-Depression-Skala. Arch Psychiatr Nervenkrank 222:359–375
Baumann U, Seidenstücker G (1977) Untersuchungsinstrumente. Zur Taxonomie und Bewertung psychologischer Untersuchungsverfahren bei Psychopharmakaprüfung. Pharmakopsychiatrie Neuro-Psychopharmakologie 3:165–175
Borbe HO, Müller WE (1984) Amitriptylinoxid — Ein Fortschritt in der Therapie mit trizyklischen Antidepressiva? Medizinische Welt 35:1438–1442
Borromei A (1982) A new antidepressant agent: Amitriptyline-N-oxide. Adv Biochem Psychopharm 32:43–47
Benkert O, Hippius H (1980) Psychiatrische Pharmakotherapie, 3. Auflage. Springer, Berlin Heidelberg New York
Busch H, Müller-Oerlinghausen B (1978) Psychopharmaka. In: Kuemmerle HP (Hrsg) Methoden der Klinischen Pharmakologie. München, Urban und Schwarzenberg
Campbell DT, Fiske DW (1959) Convergent and discriminant validation by the multitrait multimethod matrix. Psychol Bull 56:81–105
Cassano GB, Conti L, Dell'Osso L, Massimetti G (1982) Four new atypical antidepressants (Trazodone, Mianserin, Nomifensine, Caroxazone): Results of controlled trials. Adv Biochem Psychopharm 32:125–139
Cassano GB, Conti L, Massimetti G, Fornaro P, Re F (1983) A controlled clinical trial between amitriptyline and its N-oxide metabolite. Psychopharmacology Bulletin 19, 1:98–103
CIPS (1981) Internationale Skalen für die Psychiatrie. Beltz, Weinheim
Costa E, Racagni G (eds) (1982) Typical and atypical antidepressants. In: Advances in biochemical psychopharmacology, vol 32. Raven Press, New York
Debus G (1974) Selbst- und Fremdeinstufung des aktuellen Befindens in psychopharmakologischen Längsschnittuntersuchungen. Arzneimittel-Forschung 24:996–1001
Edwards BC, Lambert MJ, Moran PW, McCully T, Smith KC, Ellington AG (1984) A meta-analytic comparison of the Beck Depression Inventory and the Hamilton Rating Scale for Depression as measured of treatment outcome. Br J Clin Psychol 23:93–99
Fahrenberg J, Kuhn M, Kulick B, Myrtek M (1977) Methodenentwicklung für psychologische Zeitreihenstudien. Diagnostika 23:15–36
Fahrenberg J (1984) Methodische Überlegungen zur Mehrebenen-Prozeßforschung. In: Baumann U (Hrsg) Psychotherapie: Makro/Mikroperspektive. Hogrefe, Göttingen
Greef K, Köhler E (1977) Vergleich der Wirkung von Amitriptylin und Amitriptylin-N-oxid auf Herz und Kreislauf. Herz/Kreislauf 9:17–19
Kass F, Charles E, Klein DF, Cohen P (1983) Discordance between the SCL-90 and therapist's psychopathology ratings. Implications for clinical assessment. Arch Gen Psychiat 40:389–393
Kazdin AE (1980) Research in clinical psychology. Harper and Row Publishers, New York
Kerr TA, McClelland HA, Stephens DA, Ankier SI (1984) Trazodone—A comparative clinical and predictive study. Acta Psychiatr Scand 70:573–577
Kieback D (1982) Vergleich der Hamilton Rating Scale for Depression (HRS) mit der v. Zerssen-Befindlichkeitsskala (BS) am Beispiel einer klinischen Prüfung von Trazodon versus Amitriptylin. Pharmacopsychiatry 15:97–101
Lehrl S, Gallwitz A, Nusko G, Burkard G (1977) Warum geben Selbstbeurteilungsverfahren schwere Depressionen falsch wieder? Empirische Untersuchungen zur Einschränkung verschiedener Erklärungsmöglichkeiten. Therapeutische Umschau 10:687–693
Leuschner F, Neumann W, Doppelfeld IS, Erdös A, Fontaine R, Gabbar HA, Graf E (1978) General pharmacology of amitriptylinoxide. Arzneimittel-Forschung/Drug Res 28:1883–1893
Lienert GA (1978) Verteilungsfreie Methoden in der Biostatistik, Bd II. A Hain, Meisenheim an der Glan
McNair DM (1974) Original investigations self-evaluations of anti-depressants. Psychopharmacologia 37:281–302
Netter P, Beckmann H (1985) Procedings of the Congress of the AGNP Nürnberg 1983. Pharmacopsychiatry 18:1–178 (S 80 ff)
Peterson L (1983) A brief methodological comment on possible inaccuracies induced by multimodal measurement analysis and reporting. J Behav Med 7:307–313
Platz W, Bartsch H (1984) Therapie depressiver Patienten — Doppel-blindstudie Amitriptylin versus Amitriptylinoxid (Equilibrin® 30/60). Der Allgemeinarzt 6, 6:548–552
Rapp W (1978) Comparative trial of amitriptyline-N-oxide and amitriptyline in the treatment of out-patients with depressive syndromes. Acta Psychiatr Scand 58:245–255
Seefried S (1982) Equilibrin® bei älteren depressiven Patienten. Ergebnisse einer Therapiestudie. ZFA, 58:35/36
Seidenstücker G, Baumann U (1978) Multimethodale Diagnostik. In: Baumann U, Berbalk H, Seidenstücker G (Hrsg) Klinische Psychologie — Trends in Forschung und Praxis, Bd 1. Huber, Bern
Shapiro MB, Post F (1974) Comparison of self-ratings of psychiatric patients with ratings made by a psychiatrist. Br J Psychiatr 125:36–41
Simhandl Ch, Rogan M, Lesch ON, Musalek M, Strobl R (1984) Wertigkeit von Fremd- und Selbstbeurteilungsskalen bei chronisch Schizophrenen. Nervenarzt 55:371–377
Waskoff JE, Parloff MB (1975) Psychotherapy change measures. Rockvielle, MD, Nat Inst Ment Health
Wenzl H (1978) Special experiments on central nervous effects of amitriptyline oxide considering pharmacokinetic aspects. Arzneimittelfoschung/Drug Res 28:1879–1883
Wiggins JS (1973) Personality and prediction. Principles of personality assessment. Addison-Wesley, Reading, MA
Zerssen D v (1976) Klinische Selbstbeurteilungsskalen Kst.-S. Allgemeiner Teil, Manual. Beltz, Weinheim
Zerssen D v, Möller HJ (1980) Psychopathometrische Verfahren in der psychiatrischen Therapieforschung. In: Biefang S (Hrsg) Evaluationsforschung in der Psychiatric: Fragestellungen und Methoden. Enke, Stuttgart
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Baumann, U., Eckmann, F. & Stieglitz, R.D. Self-rating data as a selecting factor in clinical trials of psychotropic drugs. Eur Arch Psychiatr Neurol Sci 235, 65–70 (1985). https://doi.org/10.1007/BF00633474
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00633474