Summary
The present study shows that nifedipine, nimodipine and nisoldipine inhibit in vitro agonist-induced prostacyclin (PGI2) release from rat aortic rings. The agonists used were: U46619 (a thromboxane A2 analogue); A23187 (a calcium ionophore) and adrenaline.
In contrast, these calcium channel blockers did not inhibit in vitro trauma-or arachidonic acid (AA)-induced PGI2 release. Therefore, in vitro PGI2 release, models may be calcium channel dependent (adrenaline, U46619, A23187) or independent (trauma, AA), a property which is relevant to calcium channel blocker research. It is suggested that calcium channel dependent PGI2 release is relevant to modulating the relaxation phase of muscle contraction, while calcium channel independent PGI2 release is relevant to limiting the extension of thrombi following local vascular trauma.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Blair IA, Barrow SE, Waddell KA, Lewis PJ, Dollery CT (1982) Prostacyclin is not a circulating hormone in man. Prostaglandins 23:579–589
Christ-Hazelhof E, Nugteren DH (1981) Prostacyclin is not a circulating hormone. Prostaglandins 22:739–746
Davi G, Novo, S, Fiore et al. (1982) Effects of nifedipine on thromboxane synthesis in vivo and in vitro. Thromb Res 28:837–842
Exton HJ (1980) Mechanisms involved in adrenergic phenomena: role of calcium ions in actions of catecholamines in liver and other tissues. Am J Physiol 238:E3-E12
Hong SL, Deykin D (1982) Activation of phospholipase A2 and C in pig aortic endothelial cells synthesising prostacyclin. J Biol Chem 257:7151–7154
Jeremy JY, Mikhailidis DP, Dandona P (1984a) Vascular trauma and prostacyclin release. Microcirc Endothel Lymph 1:629–644
Jeremy JY, Mikhailidis DP, Dandona P (1984b) The urinary bladder synthesises prostacyclin as well as other prostanoids. Prost Leuk Med 16:235–248
Jeremy JY, Mikhailidis DP, Dandona P (1985a) Thromboxane A2 analogue U46619 stimulates vascular PGI2 synthesis. Eur J Pharmacol 107:259–262
Jeremy JY, Mikhailidis DP, Dandona P (1985b) Adrenergic modulation of vascular prostacyclin (PGI2) secretion. Eur J Pharmacol 114:33–40
Mikhailidis DP, Jeremy JY, Barradas MA, Green N, Dandona P (1983) Effect of ethanol on vascular prostacyclin (prostaglandin I2) synthesis, platelet aggregation and platelet thromboxane release. Br Med J 287:1495–1498
Moncada S, Vane JR (1979) Prostacyclin formation and effects. In: Roberts SM, Scheimann F (eds) Chemistry, biochemistry and pharmacological activity of prostanoids. Pergamon Press, Oxford, pp 258–273
Nayler WG (1980) Calcium antagonists. Eur Heart J 1:225–237
Onada JM, Sloan BF, Honn KV (1984) Antithrombotic effects of calcium channel blockers: Synergism with prostacyclin and thromboxane synthase inhibitors. Thromb Res 34:367–378
Reed PW, Lardy HA (1972) A23187: A divalent cation ionophore. J Biol Chem 247:6970–6977
Ritter JM, Barrow SE, Blair IA, Dollery CT (1983) Release of prostacyclin in vivo and its role in man. Lancet I:317–319
Symposium (organised by P. M. Vanhoutte) (1984) Calcium entry blockers and vascular disease. International Angiology 3:5–81
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jeremy, J.Y., Mikhailidis, D.P. & Dandona, P. The effect of nifedipine, nimodipine and nisoldipine on agonistand trauma-stimulated vascular prostacyclin synthesis in vitro. Naunyn-Schmiedeberg's Arch. Pharmacol. 332, 70–73 (1986). https://doi.org/10.1007/BF00633200
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00633200