Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 332, Issue 1, pp 62–65 | Cite as

Capsaicin-sensitive afferent neurones and gastrointestinal propulsion in the rat

  • P. Holzer
Article

Summary

  1. 1.

    Gastrointestinal propulsion (gastric emptying and gastrointestinal transit) of a test meal containing charcoal and51Cr as well as defaecation in relation to food intake were studied in adult rats pretreated with capsaicin (0.40 mmol kg−1 S.C.) or its solvent one week before experimentation.

     
  2. 2.

    In solvent-treated rats, gastrointestinal propulsion did not differ when the test meal was given to conscious animals or when the meal was administered under ether anaesthesia. In rats treated with capsaicin, gastrointestinal propulsion was unchanged as compared with solvent-treated rats when the test meal was administered to conscious animals. When, however, the meal was given under ether anaesthesia capsaicin-treated rats showed a delayed gastrointestinal propulsion as compared with solventtreated rats. This delay in gastrointestinal propulsion was abolished by pretreatment of the animals with guanethidine (67 μmol kg−1 S.C.).

     
  3. 3.

    Rats treated with capsaicin exhibited a prolonged sleeping time in response to ether as compared with solventtreated rats.

     
  4. 4.

    Defaecation in relation to food intake was not changed in rats treated with capsaicin as compared with solvent-treated animals.

     
  5. 5.

    These results indicate that capsaicin-sensitive afferent neurones do not participate in the physiologic control of gastrointestinal propulsion. The delay in gastrointestinal propulsion observed in capsaicin-treated rats when fed under ether anaesthesia seems to involve the sympathetic nervous system. This finding suggests that secondary functional changes in the autonomic nervous system following capsaicin treatment can influence physiologic processes in which capsaicin-sensitive afferent neurones are not primarily implicated.

     

Key words

Capsaicin Capsaicin-sensitive afferent neurones 

Gastrointestinal propulsion in the rat

Gastric emptying Gastrointestinal transit Defaecation in relation to food intake 

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References

  1. Barthó L, Szolcsányi J (1978) The site of action of capsaicin on the guinea-pig isolated ileum. Naunyn-Schmiedeberg's Arch Pharmacol 305:75–81Google Scholar
  2. Barthó L, Szolcsányi J (1980) The mechanism of the motor response to periarterial nerve stimulation in the small intestine of the rabbit. Br J Pharmacol 70:193–195Google Scholar
  3. Cervero F, McRitchie HA (1982) Neonatal capsaicin does not affect unmyelinated efferent fibres of the autonomic nervous system: functional evidence. Brain Res 239:283–288Google Scholar
  4. Costa M, Furness JB (1982) Nervous control of intestinal motility. In: Bertaccini G (ed) Handbook of Experimental Pharmacology, vol 59/I. Springer, Berlin, pp 279–382Google Scholar
  5. Donnerer J, Barthó L, Holzer P, Lembeck F (1984) Intestinal peristalsis associated with release of immunoreactive substance P. Neuroscience 11:913–918Google Scholar
  6. Fehér E, Vajda J (1982) Effect of capsaicin on the nerve elements of the small intestine. Acta Morphol Acad Sci Hung 30: 57–63Google Scholar
  7. Furness JB, Papka RE, Della NG, Costa M, Eskay RL (1982) Substance P-like immunoreactivity in nerves associated with the vascular system in guinea-pigs. Neuroscience 7:447–459Google Scholar
  8. Gamse R (1982) Capsaicin and nociception in the rat and mouse. Naunyn-Schmiedeberg's Arch Pharmacol 320:205–216Google Scholar
  9. Hayes AG, Skingle M, Tyers MB (1981) Effects of single doses of capsaicin on nociceptive thresholds in the rodent. Neuropharmacology 20:505–511Google Scholar
  10. Holzer P (1985) Stimulation and inhibition of gastrointestinal propulsion induced by substance P and substance K in the rat. Br J Pharmacol (in press)Google Scholar
  11. Holzer-Petsche U, Lembeck F (1984) Systemic capsaicin treatment impairs the micturition reflex in the rat. Br J Pharmacol 83:935–941Google Scholar
  12. Hoyes AD, Barber P (1981) Degeneration of axons in the ureteric and duodenal nerve plexuses of the adult rat following in vivo treatment with capsaicin. Neurosci Lett 25:19–24Google Scholar
  13. Jancsó-Gábor A (1980) Anaesthesia-like condition and/or potentiation of hexobarbital sleep produced by pungent agents in normal and capsaicin-desensitized rats. Acta Physiol Acad Sci Hung 55:57–62Google Scholar
  14. Lembeck F, Skofitsch G (1982) Visceral pain reflex after pretreatment with capsaicin and morphine. Naunyn-Schmiedeberg's Arch Pharmacol 321:116–122Google Scholar
  15. Lidberg P (1985) On the role of substance P and serotonin in the pyloric motor control. Acta Physiol Scand Suppl 538:1–69Google Scholar
  16. Longhurst JC, Ashton JH, Iwamoto GA (1980) Cardiovascular reflexes resulting from capsaicin-stimulated gastric receptors in anaesthetized dogs. Circ Res 46:780–788Google Scholar
  17. Miller MS, Brendel K, Burks TF, Sipes IG (1983) Interaction of capsaicinoids with drug-metabolizing systems. Biochem Pharmacol 32:547–551Google Scholar
  18. Nagy JI (1982) Capsaicin: a chemical probe for sensory neuron mechanisms. In: Iversen LL, Ibersen SD, Snyder SH (eds) Handbook of psychopharmacology, vol 15. Plenum Press, New York, pp 185–235Google Scholar
  19. Sharkey KA, Williams RG, Dockray GJ (1984) Sensory substance P innervation of the stomach and pancreas. Gastroenterology 87:914–921Google Scholar
  20. Szolcsányi J, Barthó L (1978) New type of nerve-mediated cholinergic contractions of the guinea-pig small intestine and its selective blockade by capsaicin. Naunyn-Schmiedeberg's Arch Pharmacol 305:83–90Google Scholar
  21. Szolcsányi J, Barthó L (1979) Capsaicin-sensitive innervation of the guinea-pig taenia caeci. Naunyn-Schmiedeberg's Arch Pharmacol 309:77–82Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • P. Holzer
    • 1
  1. 1.University Department of Experimental and Clinical PharmacologyGrazAustria

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