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In vitro susceptibility ofTrichophyton rubrum isolates to griseofulvin and tioconazole. Induction and isolation of a resistant mutant to both antimycotic drugs

Mutant of Trichophyton rubrum resistant to griseofulvin and tioconazole

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Abstract

The in vitro susceptibility of three clinicalTrichophyton rubrum isolates to griseofulvin and tioconazole, determined by the minimal inhibitory concentration (MIC), was 2 and 0.5 to 1.0μg/ml, respectively. One mutant (gril) obtained after mutagenic treatment of one of these isolates was selected and showed simultaneous resistance to griseofulvin (MIC > 2000μg/ml) and tioconazole (MIC=1.0μg/ml). The clinical importance and the possibility of a multidrug resistance (MDR)-type mechanism being involved in this event is discussed.

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Authors and Affiliations

  1. Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, USP, 14049-900, Ribeirao Preto, Sao Paulo, Brazil

    Ana Lucia Fachin & Nilce Maria Martinez-Rossi

  2. Departamento de Parasitologia Microbiologia e Imunologia, Faculdade de Medicina de Ribeirao Preto, USP, 14049-900, Ribeirao Preto, Sao Paulo, Brazil

    Claudia Maria Leite Maffei

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  1. Ana Lucia Fachin
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  2. Claudia Maria Leite Maffei
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  3. Nilce Maria Martinez-Rossi
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Correspondence to Nilce Maria Martinez-Rossi.

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Fachin, A.L., Maffei, C.M.L. & Martinez-Rossi, N.M. In vitro susceptibility ofTrichophyton rubrum isolates to griseofulvin and tioconazole. Induction and isolation of a resistant mutant to both antimycotic drugs. Mycopathologia 135, 141–143 (1996). https://doi.org/10.1007/BF00632334

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  • DOI: https://doi.org/10.1007/BF00632334

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