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An investigation of the kallikreins and the kininases and proteins bound with them in the venoms of Central Asian snakes

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Abstract

The activities of the kallikreins and the kininases and the peptides bound with them in the venoms of Central Asian snakes have been studied. It has been found that when the whole venoms are used an interference of the enzymes with one another and also with potentiating or inhibiting peptides takes place. Bradykinin-potentiating activity the nature of which is connected with an inhibiting action on kininase II has been found in the low-molecular-mass fractions of cobra and viper venoms. The inhibiting activities of the venoms have been characterized in relation to the angiotension-converting enzyme from bovine kidneys and also purified dipeptidyl carboxypeptidase from karakurt (black widow) venom.

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Authors
  1. L. Ya. Yukel'son
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  2. V. M. L'vov
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  3. N. Sultanalieva
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Additional information

Institute of Biochemistry, Uzbekistan Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 257–261, March–April, 1992.

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Yukel'son, L.Y., L'vov, V.M. & Sultanalieva, N. An investigation of the kallikreins and the kininases and proteins bound with them in the venoms of Central Asian snakes. Chem Nat Compd 28, 222–226 (1992). https://doi.org/10.1007/BF00630182

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  • DOI: https://doi.org/10.1007/BF00630182

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