Summary
The effects of occupational exposure toN,N-dimethylformamide (DMF) on sister chromatid exchange (SCE) rates were studied in peripheral lymphocytes from 22 DMF-exposed women (aged 22–52 years) in comparison with 22 sex-, age-, and residence-matched controls. All subjects were nonsmokers and nondrinkers as confirmed by medical interview. The 22 pairs were divided by the intensity of exposure to DMF into 3 subgroups of high-exposed (8 pairs with mean DMF exposure at 5.8ppm), middle-exposed (5 pairs with DMF at 0.7 ppm in combination with toluene at 0.9 ppm), and low-exposed (9 pairs with DMF at 0.3 ppm). The SCE rates were significantly higher in the high (P < 0.005) and middle (P < 0.01) exposed than in their matched pairs, and the increase was related to the intensity of DMF exposure.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Antoine JL, Arany L, Leonard A, Henrotte J, Jenar-Dubuisson G, Decat G (1983) Lack of mutagenic activity of dimethylformamide. Toxicology 26:207–212
Becci PJ, Voss KA, Johnson WD, Gallo MA, Babish JG (1983) Subchronic feeding study ofN,N-dimethylformamide in rats and mice. J Am Coll Toxicol 2:371–378
Berger H, Haber I, Wunscher G, Bittersohl G (1985) Epidemiologische Untersuchungen zur Dimethylformamidexposition (in German with an English abstract). Z Gesamte Hyg 31:366–368
Cai S-X, Huang M-Y, Xi L-Q, Li Y-L, Qu J-B, Kawai T, Yasugi T, Mizunuma K, Watanabe T, Ikeda M (1992) Occupational dimethylformamide exposure: 3. Health effects of dimethylformamide after occupational exposure at low concentrations. Int Arch Occup Environ Health (in press)
Chen JL, Fayerweather WE, Pell S (1988) Cancer incidence of workers exposed to dimethylformamide and/or acrylonitrile. J Occup Med 30:813–818
Cirla AM, Pisati G, Invernizzi E, Torricelli P (1984) Epidemiological study on workers exposed to low dimethylformamide concentrations. G Ital Med Lav 6:149–156
Craig DK, Weir RJ, Wagner W, Groth D (1984) Subchronic inhalation toxicity of dimethylformamide in rats and mice. Drug Chem Toxicol 7:551–571
Ducatman AM (1989) Dimethylformamide, metal dyes, and testicular cancer. Lancet I:911
Ducatman AM, Conwill DE, Crawl Y (1986) Germ cell tumors of the testicle among aircraft repairmen. J Urol 136:834–836
Fleming LE, Shalat SL, Redlich CA (1990) Liver injury in workers exposed to dimethylformamide. Scand J Work Environ Health 16:289–292
Hirayama T, Ikeda M (1979) Applicability of activated carbon felt to the dosimetry of solvent vapor mixture. Am Ind Hyg Assoc J 40:1091–1096
International Agency for Research on Cancer (1989) Toluene. IARC Monogr Eval Carcinag Risks Hum 47:79–123
Japan Association of Industrial Health (1991) Recommendation for occupational exposure limits (in Japanese) Jpn J Ind Health 33:277–298
Kawai T, Yasugi T, Mizunuma K, Watanabe T, Cai S-X, Huang M-Y, Xi L-Q, QU J-B, Yao B-Z, Ikeda M (1992) Occupational dimethylformamide exposure: 2. Monomethylformamide excretion in urine after occupational dimethylformamide exposure. Int Arch Occup Environ Health (in press)
Koudela K, Spazier K (1979) Influence of dimethylformamide on human peripheral lymphocytes (in Czech with English summary). Cesk Hyg 24:432–437
Lauwerys RR, Kivits A, Lhoir M, Rigolet P, Houbeau D, Buchet JP, Roels HA (1980) Biological surveillance of workers exposed to dimethylformamide and the influence of skin protection on its percutaneous absorption. In Arch Occup Environ Health 45:189–203
Levin SM, Baker DB, Landrigan PY, Monaghan SV, Framin E, Braithwaite M, Towne W (1987) Testicular cancer in leather tanners exposed to dimethylformamide. Lancet 11:1153
Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E (1986)Salmonella mutagenicity tests: II. Results from testing 270 chemicals. Environ Mutagen 8 [Suppl 7]:1–119
Pelclová D, Rössner P, Picková J (1990) Chromosome aberrations in rotogravure printing plant workers. Mutat Res 245:299–303
Redlich CA, Beckett WS, Sparer J, Barwick KW, Riely CA, Miller H, Sigal SL, Shalat SL, Cullen MR (1988) Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med 108:680–686
Redlich CA, West AB, Fleming L, True LD, Cullen MR, Riely CA (1990) Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide. Gastroenterology 99:748–757
Scailteur V, Lauwerys R (1984) In vivo metabolism of dimethylformamide and relation to toxicity in the male rat. Arch Toxicol 56:87–91
Seiji K, Jin C, Watanabe T, Nakatsuka H, Ikeda M (1990) Sister chromatid exchanges in peripheral lymphocytes of workers exposed to benzene, trichloroethylene, or tetrachloroethylene, with reference to smoking habits. Int Arch Occup Environ Health 62:171–176
Tanaka K (1971) Toxicity of dimethylformamide in the young female rat. Int Arch Arbeitsmed 28:95–105
Walrath P, Fayerweather WE, Gilby PG, Pell S (1989) A casecontrol study of cancer among Du Pont employees with potential for exposure to dimethylformamide. J Occup Med 31:432–438
Wang J-D, Lai M-Y, Chen J-S, Lin J-M, Chiang J-R, Shiau S-J, Chang W-S (1991) Dimethylformamide-induced liver damage among synthetic leather workers. Arch Environ Health 46:161–166
Yasugi T, Kawai T, Horiguchi S, Ikeda M (1992) Occupational dimethylformamide exposure: 1. Diffusive sampling of dimethlyformamide vapor for determination of time-weighted average concentration in air. Int Arch Occup Environ Health (in press)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Seiji, K., Inoue, O., Cai, SX. et al. Increase in sister chromatid exchange rates in association with occupational exposure toN,N-dimethylformamide. Int. Arch Occup Environ Heath 64, 65–67 (1992). https://doi.org/10.1007/BF00625953
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00625953