European Journal of Clinical Pharmacology

, Volume 17, Issue 4, pp 243–250 | Cite as

Digoxin concentration in right atrial myocardium, skeletal muscle and serum in man: Influence of atrial rhythm

  • T. Jogestrand


Serum, right atrial myocardium and skeletal muscle collected from 32 adult patients undergoing open heart surgery were analyzed for digoxin by radioimmunoassay. Preoperatively 20 patients were in sinus rhythm and 12 were in atrial fibrillation. In patients with sinus rhythm, but not in patients with atrial fibrillation, there was a highly significant correlation between digoxin concentration in serum and right atrial myocardium, in skeletal muscle and right atrial myocardium, and in serum and skeletal muscle. The means and variances of the ratios right atrial myocardium/serum and right atrial myocardium/skeletal muscle were significantly higher in patients with atrial fibrillation than in those with sinus rhythm. This, plus the lack of difference in ratios skeletal muscle/serum between these groups of patients, indicate increased right atrial digoxin binding in atrial fibrillation in man. This conclusion is further supported by the finding of similar or higher digoxin concentration in right atrial myocardium than in left ventricular myocardium in atrial fibrillation (6 patients), and a lower digoxin concentration in right atrial myocardium than in left ventricular myocardium in sinus rhythm (3 patients).

Key words

digoxin atrial fibrillation digoxin concentrations in right atrium skeletal muscle serum sinus rhythm man 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • T. Jogestrand
    • 1
  1. 1.Department of Clinical Physiology and Thoracic SurgeryKarolinska HospitalStockholmSweden

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