Summary
Nine previously untreated patients with mild-moderate hypertension were included in a dose-ranging double-blind trial to determine the effectiveness of daily versus thrice daily timolol administration. In 8 patients control of blood pressure was equally effective though with significantly lower heart rate achieved in the once daily group. One patient was not satisfactorily controlled on the daily regimen demonstrating that many but not all hypertensives can be controlled with daily administration of timolol.
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Edwards, I.R., Else, O. Once-daily dosing of timolol in hypertension: A controlled study. Eur J Clin Pharmacol 17, 239–241 (1980). https://doi.org/10.1007/BF00625796
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DOI: https://doi.org/10.1007/BF00625796