Abstract
Measurements of splenic respiratory gas exchange and of HbO2 saturations in the red pulp of the rat spleen have shown that there are no indications of a reduced intrasplenic O2 availability during normoxia. The present studies provide evidence that, in the normal spleen, the intrasplenic sequestration of red blood cells cannot be explained by an O2 deficiency in the red pulp since the commonly accepted notion of an intrasplenic hypoxia is not true.
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Bork, R., Vaupel, P., Thews, G.: Atemgas-pH- Nomogramme für das Rattenblut bei 37°C. Anaesthesist24, 84–90 (1975).
Groom, A. C., Levesque, M. J., Brucksweiger, D.: Flow stasis, blood gases and glucose levels in the red pulp of the spleen. Advan. Exptl. Med. Biol.94, 567–572 (1978).
Grunewald, W. A., Lübbers, D. W.: Die Bestimmung der intracapillären HbO2-Sättingung mit einer kryo- mikrofotometrischen Methode angewandt am Myocard des Kaninchens. Pflügers Arch.353, 255–273 (1975).
Heimpel, H.: Die Milz bei hämolytischen Anämien. In: Die Milz/The Spleen (K. Lennert, D. Harms, eds.), Berlin-Heidelberg-New York: Springer 1970.
Jandl, J. H.: Hereditary spherocytosis. In: Hereditary Disorders of Erythrocyte Metabolism (E. Beutler, ed.), New York-London: Grune and Stratton 1968.
Jandl, J. H., Aster, R. H.: Increased splenic pooling and the pathogenesis of hypersplenism. Am. J. Med. Sci.253, 383–397 (1967).
LaCelle, P. L.: Alteration of membrane deformability in hemolytic anemias. Seminars in Hematol.7, 355–371 (1970).
LaCelle, P. L., Weed, R. I.: The contribution of normal and pathologic erythrocytes to blood rheology. Progr Hematol.7, 1–31 (1971).
Levesque, M. J., Groom, A. C.: pH environment of red cells in the spleen. Am. J. Physiol.231, 1672–1678 (1976).
Murphy, J. R.: The influence of pH and temperature on some physical properties of normal erythrocytes and erythrocytes from patients with hereditary spherocytosis. J. Lab. Clin. Invest.69, 758–775 (1967).
Vaupel, P., Braunbeck, W., Thews, G.: Respiratory gas exchange and pO2 distribution in splenic tissue. Advan. Exptl. Med. Biol.37A, 401–406 (1973).
Vaupel, P., Wendling, P., Thomé, H., Fischer, J.: Atemgaswechsel und Glucoseaufnahme der menschlichen Milz in situ. Klin. Wschr.55, 239–242 (1977).
Vaupel, P., Ruppert, H., Hutten, H.: Splenic blood flow and intrasplenic flow distribution in rats. Pflügers Arch.369, 193–201 (1977).
Vaupel, P., Manz, R., Müller-Klieser, W., Grunewald, W. A.: Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia. Microvasc. Res. (in press).
Wendling, P., Vaupel, P., Fischer, J., Brünner, H.: Splenic respiratory gas exchange and glucose uptake in patients with splenomegaly in hypersplenism and Hodgkin's disease. Klin. Wschr.55, 1057–1061 (1977).
Wennberg, E., Weiss, L.: The structure of the spleen and hemolysis. Ann. Rev. Med.20, 29–40 (1969).
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Vaupel, P., Manz, R. & Müller-Klieser, W. Respiratory gas exchange in the rat spleen in situ and intrasplenic oxyhemoglobin saturation. Pflugers Arch. 379, 109–111 (1979). https://doi.org/10.1007/BF00622913
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DOI: https://doi.org/10.1007/BF00622913