Abstract
The effect of mucosal La3+ on electrical parameters of isolated frog skins was studied on isolated frog skins with normally polarized or depolarized apical membrane. La3+ increases Rs, the paracellular or shunt resistance and diminishes RNa, the resistance of the active sodium path, in both polarized and depolarized skins.
The stimulatory effect of La3+ on short-circuit current (Is.c.) is correlated with this decrease in RNa. The characteristics of the stimulatory effect are: very rapid onset, ionic strength dependency, the possibility of being elicited by many other ions besides La3+. These features allow us to postulate that La3+ might affect the external interfacial potential which in turn affects the resistance of the sodium path.
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Goudeau, H., Wietzerbin, J. & Gary-Bobo, C.M. Effects of mucosal lanthanum on electrical parameters of isolated frog skin. Pflugers Arch. 379, 71–80 (1979). https://doi.org/10.1007/BF00622907
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DOI: https://doi.org/10.1007/BF00622907