Summary
A series of cobalt(II) and nickel(II) 2-X-1,3,4-thiadiazole complexes (X=Cl or Br) were investigated by electronic, n.m.r., Raman and i.r. spectroscopy, and by thermogravimetric analyses, magnetic moments and conductivity measurements.
The complexes havepseudo-tetrahedral or pseudo-octa-hedral stereochemistries with MN2X2 (X=Cl or Br), MN4X2 (X=Cl, Br or O) or MN3O3 chromophores.
The ligands are mono- or bi-dentate without involving the sulphur atom. Surprisingly, the chloro-derivative ligand seems to be more nucleophilic than the bromo-analogue.
The computed (CNDO/2) molecular orbital indices for the uncomplexed ligands indicate that the coordination sites are the nitrogen atoms.
In connection with our previous work(1) on the coordination ability of heterocyclic ligands with interesting biological(2,3) and pharmaceutical(4) properties and containing endocyclic nitrogen and sulphur donor atoms, we have considered the 1,3,4-thiadiazole ring, which is the main framework of a very important class of diuretic drugs, the sulphonamide inhibitors(5) of the zinc m tallo-enzyme carbonic anhydrase.
In this study we have investigated the coordination behaviour of the 2-chloro-1,3,4-thiadiazole(ctz) and the 2-bromo-1,3,4-thiadiazole (btz).
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Benedetti, A., De Benedetti, P.G., Fabretti, A.C. et al. Coordination behaviour of 2-halo-1,3,4-thiadiazoles towards cobalt(ii) and nickel(ii). Transition Met Chem 9, 457–460 (1984). https://doi.org/10.1007/BF00620677
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DOI: https://doi.org/10.1007/BF00620677