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Untersuchungen über die Löslichkeit von Hautkollagen bei Sklerodermie und den Effekt vond-Penicillamin

Studies on the solubility of skin collagen in scleroderma and the effect ofd-penicillamine

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Summary

Biopsy specimens were taken from 18 patients with generalised and circumscribed scleroderma and from 8 control subjects. Solubility of collagen of affected and unaffected skin areas was studied. In comparison with other methods, the amount of dissolved material obtained by use of 8.0 M urea was ten times larger. The solubility of collagen is higher in scleroderma than in normal skin. Long-time treatment withd-Penicillamine normalized this collagen solubility pattern. It is suggested that in scleroderma a disturbance of collagen crosslinking is an important factor.

Zusammenfassung

An Biopsiematerial von 18 Patienten mit diffuser (progressiver) und circumscripter Sklerodermie und 8 Kontrollpersonen wurde das Löslichkeitsverhalten von Kollagen klinisch gesund erscheinender und erkrankter Hautareale untersucht. Durch die Anwendung von 8,0 M Harnstoff konnte die Ausbeute an gelöstem Material gegenüber anderen Verfahren etwa verzehnfacht werden. Die Löslichkeit nimmt in der Reihenfolge gesunde Haut < klinisch nicht befallene Haut < erkrankte Haut zu. Nach langdauernder Behandlung mitd-Penicillamin ändert sich das krankhafte Kollagenlöslichkeitsverhalten im Sinne einer Normalisierung. Die vorliegenden Befunde sprechen insgesamt dafür, daß bei Sklerodermie die Kollagenquervernetzung gestört ist.

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Authors and Affiliations

  1. Max-Planck-Institut für Eiweiß- und Lederforschung, Abteilung Kühn, Germany

    B. K. Zimmermann

  2. Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Germany

    B. -R. Balda

Authors
  1. B. K. Zimmermann
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  2. B. -R. Balda
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Zimmermann, B.K., Balda, B.R. Untersuchungen über die Löslichkeit von Hautkollagen bei Sklerodermie und den Effekt vond-Penicillamin. Arch. Derm. Forsch. 243, 357–363 (1972). https://doi.org/10.1007/BF00620417

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  • DOI: https://doi.org/10.1007/BF00620417

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