Summary
The anticholinergic compound Acabel (the benzilic acid ester of N,N-dimethyl-2-hydroxy-methyl-piperidinium-methyl sulphate), tritium labelled in the piperidine molecule, was administered to 6 healthy voltunteers. Its absorption was measured by comparing the radioactivity in gastrointestinal aspirates with that of an unabsorbed marker. The main uptake of Acabel was localized in the upper part of the small intestine, and amounted to 10–20% of the given dose. — Studiesin vitro showed that3H-Acabel can be metabolized in the small intestine. However,in vivo there was no evidence of its decomposition while the test solution was passing through the proximal part of the digestive tract.
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Beermann, B., Hellström, K. & Rosén, A. Uptake in the human small intestine of a quaternary anticholinergic compound (Acabel). Eur J Clin Pharmacol 3, 93–96 (1971). https://doi.org/10.1007/BF00619300
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DOI: https://doi.org/10.1007/BF00619300